postherpetic neuralgia


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neuralgia

 [noo͡-ral´jah]
pain in a nerve or along the course of one or more nerves, usually consisting of a sharp, spasmlike pain that may recur at intervals. It is caused by inflammation of or injury to a nerve or group of nerves. Inflammation of a nerve, or neuritis, may affect different parts of the body, depending upon the location of the nerve. Two common types of neuralgia are that of the trigeminal nerve (see tic douloureux) and that of the sciatic nerve (see sciatica). adj., adj neural´gic.
neuralgia facia´lis ve´ra Ramsay Hunt syndrome.
Fothergill's neuralgia tic douloureux (trigeminal neuralgia).
geniculate neuralgia Ramsay Hunt syndrome.
glossopharyngeal neuralgia that affecting the petrosal and jugular ganglion of the glossopharyngeal nerve, marked by severe paroxysmal pain originating on the side of the throat and extending to the ear.
Hunt's neuralgia Ramsay Hunt syndrome.
idiopathic neuralgia neuralgia of unknown etiology, not accompanied by any structural change.
intercostal neuralgia neuralgia of the intercostal nerves, causing pain in the side.
mammary neuralgia neuralgic pain in the breast.
Morton's neuralgia tenderness or pain in the metatarsal area of the foot and in the third and fourth toes caused by pressure on a neuroma of the branch of the medial plantar nerve supplying these toes. The neuroma is produced by chronic compression of the nerve between the metatarsal heads. Called also Morton's foot or toe.
The pain of Morton's neuralgia is frequently made worse with prolonged standing or walking. From Waldman, 2002.
nasociliary neuralgia pain in the eyes, brow, and root of the nose.
postherpetic neuralgia persistent burning pain and tingling along the distribution of a cutaneous nerve following an attack of herpes zoster.
trifacial neuralgia (trigeminal neuralgia) tic douloureux.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

postherpetic neuralgia (PHN),

causalgia and hyperesthesia in the dermatome served by a spinal nerve infected by herpes zoster, persisting after resolution of the skin eruption; typically occurs in middle-aged and old people; may continue for weeks, months, or years.
Farlex Partner Medical Dictionary © Farlex 2012

postherpetic neuralgia

Shingles Neurology A painful, residuum of nerve injury post-shingles/herpes zoster, due to a reactivation of HZV. See Lidoderm®.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Postherpetic neuralgia (PHN)

Persistent pain that occurs as a complication of a herpes zoster infection. Although the pain can be treated, the response is variable.
Mentioned in: Neuralgia, Shingles
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Efficacy for prevention of postherpetic neuralgia was 91.2% (95% CI = 75.9-97.7) in adults aged [greater than or equal to] 50 years and 88.8% (95% CI = 68.7-97.1) in those aged [greater than or equal to] 70 years (15).
The subject was a 75-year-old woman who had suffered from postherpetic neuralgia for 8 years.
Herpes zoster, a reactivation of the varicella virus that lies dormant in dorsal root or cranial nerve ganglia from earlier infection, is seen in about 1 million cases per year in the United States, with about 100,000-200,000 cases of postherpetic neuralgia occurring, said Jeffrey Cohen, MD, chief of the laboratory of infectious diseases at the National Institute of Allergy and Infectious Diseases, Bethesda, Md.
Postherpetic neuralgia occurs in approximately 20% of patients and can decrease quality of life, particularly in the elderly.
In postherpetic neuralgia, the C fibres are anatomically intact but abnormally hyperactive, which lowers the action potential threshold, and increases their magnitude and discharge rate (Gharibo & Kim, 2011).
Pathogenesis of Postherpetic Neuralgia. Reactivation and subsequent replication of latent VZ viruses (VZVs) in neural cells of the dorsal root ganglia induce both direct cytopathic damage to central and peripheral neurons, and VZV-mediated inflammatory tissue damage will exaggerate the neuralgic pain [2, 6].
In some patients, pain does not resolve when the rash heals but continues for weeks, months or years; this persistent, neuropathic pain is termed postherpetic neuralgia (PHN)(3,4).
Postherpetic neuralgia was most commonly observed in patients with thoracic segment16 (64%), followed by cranial 6 (24%), lumbar 2 (8%) and cervical 1 (4%).
Marco Pappagallo, M.D.,* Anne Louise Oaklander, Heterogenous Patterns of Sensory Dysfunction in Postherpetic Neuralgia Suggest Multiple Pathophysiologic Mechanisms, Anesthesiology 2000; 92:691-8).8
Oral steroids are often given to reduce the pain of shingles, as well as to prevent postherpetic neuralgia. Take whatever painkillers work for you that do the least harm.
* Postherpetic neuralgia is defined as pain that persists or relapses within 30- 120 days at the site of acute herpes zoster after rash healing.
Postherpetic neuralgia or chronic pain is the most common complication of shingles, which can last for months, even years.