The paper describes a series of in vitro studies of pharmacodynamic parameters of exebacase against Staph aureus, including the postantibiotic effect
, or PAE, postantibiotic sub-minimum inhibitory concentration, or MIC, effect and sub-MIC effect.
of purified melittin from honeybee (Apis mellifera) venom against Escherichia coli and Staphylococcus aureus.
Doxycycline is bacteriostatic and lacks concentrationdependent activity or a postantibiotic effect
, which might limit its efficacy for serious Y.
Aminoglycoside antibiotics operate via a concentration dependent killing and a postantibiotic effect
. Hence, once-daily dosing regimens were introduced that are considered less nephrotoxic .
The postantibiotic effect
of antifungal agents against common pathogenic yeasts.
It has an antibacterial spectrum equal to or broader than other fluoroquinolones, a marked postantibiotic effect
, and excellent activity against Enterobacteriaceae and other gram-negative bacteria.
 Hostacka A In vitro postantibiotic effect
of imipenem and enoxacin alone and in combination against Pseudomonas aeruginosa.
At lower concentrations, bacteria were significantly inhibited, with a clear postantibiotic effect
even at such a low dose as 0.0075 mg per milliliter.
Tigecycline's extended postantibiotic effect
is probably attributable to its long half-life, which is about 42 hours, Dr.
The mechanisms of action of aminoglycosides are readily found in many texts and will not be addressed here, with the exception of the postantibiotic effect
. By definition, postantibiotic effect
is the period of continued growth suppression after cessation of exposure of the bacteria to an active antibiotic (17-19).
These agents demonstrate a postantibiotic effect
against many gram-positive and gramnegative organisms. This inherent antimicrobial activity enables continued suppression of bacterial replication after exposure to subinhibitory concentrations of quinolones.
Vancomycin exhibits a complex pharmacokinetics, with time-dependent bactericidal effect and moderate postantibiotic effect
. It also has poor tissue penetration, and some authors question its effectiveness in severe infections.