The paper describes a series of in vitro studies of pharmacodynamic parameters of exebacase against Staph aureus, including the
postantibiotic effect, or PAE, postantibiotic sub-minimum inhibitory concentration, or MIC, effect and sub-MIC effect.
Postantibiotic effect of purified melittin from honeybee (Apis mellifera) venom against Escherichia coli and Staphylococcus aureus.
Doxycycline is bacteriostatic and lacks concentrationdependent activity or a
postantibiotic effect, which might limit its efficacy for serious Y.
Aminoglycoside antibiotics operate via a concentration dependent killing and a
postantibiotic effect. Hence, once-daily dosing regimens were introduced that are considered less nephrotoxic [20].
The
postantibiotic effect of antifungal agents against common pathogenic yeasts.
It has an antibacterial spectrum equal to or broader than other fluoroquinolones, a marked
postantibiotic effect, and excellent activity against Enterobacteriaceae and other gram-negative bacteria.
[34] Hostacka A In vitro
postantibiotic effect of imipenem and enoxacin alone and in combination against Pseudomonas aeruginosa.
At lower concentrations, bacteria were significantly inhibited, with a clear
postantibiotic effect even at such a low dose as 0.0075 mg per milliliter.
Tigecycline's extended
postantibiotic effect is probably attributable to its long half-life, which is about 42 hours, Dr.
The mechanisms of action of aminoglycosides are readily found in many texts and will not be addressed here, with the exception of the
postantibiotic effect. By definition,
postantibiotic effect is the period of continued growth suppression after cessation of exposure of the bacteria to an active antibiotic (17-19).
These agents demonstrate a
postantibiotic effect against many gram-positive and gramnegative organisms.[2] This inherent antimicrobial activity enables continued suppression of bacterial replication after exposure to subinhibitory concentrations of quinolones.
Vancomycin exhibits a complex pharmacokinetics, with time-dependent bactericidal effect and moderate
postantibiotic effect. It also has poor tissue penetration, and some authors question its effectiveness in severe infections.
