Burnett adds that while his caution for the company's MS program is in line with consensus view, he believes the Street is "missing" that success in
post-transplant lymphoproliferative disorder study would "validate" its HLA approach.
The United States Food and Drug Administration (FDA) has granted Orphan Drug Designations (ODD) to United States-based Viracta Therapeutics, Incorporated's Phase two drug candidate, nanatinostat, in combination with the antiviral valganciclovir intended for the treatment of
post-transplant lymphoproliferative disorder (PTLD), plasmablastic lymphoma, and angioimmunoblastic T cell lymphoma, it was reported yesterday.
Post-transplant lymphoproliferative disorder - the potential of proliferation signal inhibitors.
Magee, "Limitations of EBV-PCR monitoring to detect EBV associated
post-transplant lymphoproliferative disorder," Pediatric Transplantation, vol.
Harmon, "
Post-transplant lymphoproliferative disorder in the United States: Young Caucasian males are at highest risk," American Journal of Transplantation, vol.
Identifying the patient at risk for
post-transplant lymphoproliferative disorder. Transpl Infect Dis.
Leblond et al., "Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell
post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial," The Lancet Oncology, vol.
The virus can then reawaken and drive the development of B cell cancers like AIDS-associated B cell lymphoma and
post-transplant lymphoproliferative disorder.
But while recovering from the transplant, a PET scan revealed she had developed
post-transplant lymphoproliferative disorder (PTLD), a condition which can lead to cancer.
* Those also occurring in other immunodeficiency states such as
post-transplant lymphoproliferative disorder. (11)