post-transplant lymphoproliferative disorder


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post-transplant lymphoproliferative disorder

A family of Epstein-Barr virus-associated lymphoid expansions with a range of histologies, from infectious mononucleosis-like lymphoid hyperplasia to monoclonal neoplasms, that may not be classifiable as specific types of non-Hodgkin lymphoma, even if typical genetic defects are present. Monoclonal post-transplant lymphoproliferative disorders (PTLDs) do not regress when immunosuppression is withdrawn. PTLD occurs in 1–10% of organ transplant recipients; most cases that occur in solid organ recipients are of host origin.

Diagnosis
Post-transplant patients at risk for PTLD can be identified by detecting expression (as small mRNA) of the EBER-1 gene.

Note
Malignant features may regress with reduced immunosuppression.
References in periodicals archive ?
Burnett adds that while his caution for the company's MS program is in line with consensus view, he believes the Street is "missing" that success in post-transplant lymphoproliferative disorder study would "validate" its HLA approach.
The United States Food and Drug Administration (FDA) has granted Orphan Drug Designations (ODD) to United States-based Viracta Therapeutics, Incorporated's Phase two drug candidate, nanatinostat, in combination with the antiviral valganciclovir intended for the treatment of post-transplant lymphoproliferative disorder (PTLD), plasmablastic lymphoma, and angioimmunoblastic T cell lymphoma, it was reported yesterday.
Post-transplant lymphoproliferative disorder - the potential of proliferation signal inhibitors.
Magee, "Limitations of EBV-PCR monitoring to detect EBV associated post-transplant lymphoproliferative disorder," Pediatric Transplantation, vol.
Harmon, "Post-transplant lymphoproliferative disorder in the United States: Young Caucasian males are at highest risk," American Journal of Transplantation, vol.
Analysis of factors that influence survival with post-transplant lymphoproliferative disorder in renal transplant recipients: the Israel Penn International Transplant Tumor Registry experience.
Identifying the patient at risk for post-transplant lymphoproliferative disorder. Transpl Infect Dis.
Cell Medica, a leader in developing, marketing and manufacturing cellular therapeutics for cancer and viral infections, has received European Commission orphan drug designations for CMD-003 (baltaleucel-T) as a treatment for extranodal NK/T-cell lymphoma, nasal type, and post-transplant lymphoproliferative disorder.
Leblond et al., "Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial," The Lancet Oncology, vol.
The virus can then reawaken and drive the development of B cell cancers like AIDS-associated B cell lymphoma and post-transplant lymphoproliferative disorder.
But while recovering from the transplant, a PET scan revealed she had developed post-transplant lymphoproliferative disorder (PTLD), a condition which can lead to cancer.
* Those also occurring in other immunodeficiency states such as post-transplant lymphoproliferative disorder. (11)

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