The role of post-translational modifications
for learning and memory formation.
(PTMs) of histones (including acetylation, phosphorylation and methylation) regulate chromatin structure and function.
It has long been suspected that phosphorylation, a type of post-translational modification
, may be involved in the process.
Liebler points out that in the almost universally applicable field of proteomics, there are really only a few types of experiments: analysis of intact proteins using very high-resolution mass spectrometry (MS), comparative analysis of peptide mass fingerprints and genomic databases, peptide sequence analysis of 5-20 residues followed by genome mining, and de novo peptide sequencing with post-translational modification
and molecular assembly.
of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA.
We also identified receptors involved in the perception of these peptide hormones and two important transferases required for post-translational modification
of the hormones.
Proteomewide post-translational modification
statistics: frequency analysis and curation of the swiss-prot database.