post-translational modification


Also found in: Encyclopedia, Wikipedia.

post-translational modification

A generic term for any modification of a protein which occurs after translation and release from ribosomes—e.g., phosphorylation, sumoylation, proteolytic cleavage, glycosylation and acetylation.
References in periodicals archive ?
com/prnh/20130307/600769 The term lysosomal storage diseases refers to a group of rare inherited disorders caused by the deficiency of lysosomal enzymes, activator proteins, proteins required for normal post-translational modification of lysosomal enzymes or proteins required for intracellular transport between lysosome and other cellular compartments.
Their topics include analyzing and predicting protein post-translational modification sites, algorithm frameworks for determining the connectivity of protein disulfide, discovering three dimensional protein structures for optimal structure alignment, identifying protein complexes from protein-protein interaction networks, and using support vector machines to compare protein-related drug activity.
Scientists who use the techniques--and in many cases helped devise them--explain methods for transcriptional factor trafficking and post-translational modification, the cytoplasmic-nuclear trafficking of transcription factors, post-translational modification and impact on function, and protocols for optimizing functional assays.
Acetylation is one of the most important post-translational modification of proteins determining the structure, function and intracellular localization that plays an important role in the signal transduction pathways related to diverse cell functions, both during unstimulated and stress conditions.
This raft association suggested the possible post-translational modification of DATs with lipids, a characteristic common to many raft associated proteins.
The plant expression system provides for post-translational modification and processing to produce a recombinant gene product exhibiting enzymatic activity.
A particularly challenging area of study within proteomics is post-translational modification of proteins.
Following post-translational modification, and depending on the pH, the molecules may either be released into the environment or remain bound to the cell wall.
7] The differential responsiveness to stimulation by thyroid-stimulating hormone might be a result of post-translational modification of the receptor at various sites.
Capillary electrophoresis is being used to detect any post-translational modification differences of the proteins.
Protein phosphorylation is a post-translational modification of proteins in which a serine, a threonine, and/or tyrosine residue are phosphorylated by a protein kinase.
Currently with the US Department of Homeland Security, Ham reviews post-translational modification (PTM) of proteins, focusing on a collection of mass spectral studies of phosphorylation as a PTM of both eukaryotic and prokaryotic proteomes using the most current techniques in analytic chemistry.

Full browser ?