post-translational modification


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post-translational modification

A generic term for any modification of a protein which occurs after translation and release from ribosomes—e.g., phosphorylation, sumoylation, proteolytic cleavage, glycosylation and acetylation.
References in periodicals archive ?
The role of post-translational modifications for learning and memory formation.
Post-translational modifications (PTMs) of histones (including acetylation, phosphorylation and methylation) regulate chromatin structure and function.
It has long been suspected that phosphorylation, a type of post-translational modification, may be involved in the process.
When RLKs interact they alter each other through a process known as post-translational modification. Post-translational modification usually involves the addition or removal of small molecules, such as phosphate groups, to specific amino acids in a proteins structure to alter its activity, change which proteins it can interact with, promote its degradation or change where in the cell the protein is found.
Liebler points out that in the almost universally applicable field of proteomics, there are really only a few types of experiments: analysis of intact proteins using very high-resolution mass spectrometry (MS), comparative analysis of peptide mass fingerprints and genomic databases, peptide sequence analysis of 5-20 residues followed by genome mining, and de novo peptide sequencing with post-translational modification determination.
Chemical biology (to characterise the functions of specific post-translational modification in biochemical assays and bacterial cells).
Since discovering SUMO 20 years ago, Melchior has been instrumental in shaping and leading research on post-translational modification of proteins with SUMO.
Among these, the post-translational modification (PTM) ADP-ribosylation (ADPR) plays a decisive role in effective DDR.
Post-translational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA.
We also identified receptors involved in the perception of these peptide hormones and two important transferases required for post-translational modification of the hormones.
Proteomewide post-translational modification statistics: frequency analysis and curation of the swiss-prot database.

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