Istaroxime is an intravenously administered agent with a positive inotropic agent
that increases myocardial contractility through inhibition of Na+/K+-ATPase.
Intravenous sodium bicarbonate, saline, and positive inotropic agent
infusions were started immediately.
The chemical synthesis and the pharmacologica [studies of tetrahydroquinoline derivatives such as Sumanirole maleate (an anti-depressant for Parkinson's disease) (Hulin and Lopaze 2004) and Vesnarinone (a positive inotropic agent
) (Santangelo et al.
As such, our study results seem to suggest that determination of baseline IGF-I levels may help guide clinicians when making the decision to administer a positive inotropic agent
such as levosimendan in patients admitted with a diagnosis of decompensated HE In this study, we only assessed short-term response to levosimendan treatment.
A positive inotropic agent
that simultaneously activates intracellular [K.sub.ATP], channels is potentially protective of patients at risk of myocardial ischaemia.
When intravenous vasoactive medications are required for acute decompensated heart failure, patients who receive a vasodilator or natriuretic peptide are more likely to survive than are those who receive a positive inotropic agent
, reported William T.
"This herb is a positive inotropic agent
that increases contractility of the heart," said Dr.
The search for the ideal positive inotropic agent
. N Engl J Med 1993; 329: 201-2.
Pimobendan is a phosphodiesterase III inhibitor and calcium channel sensitizer causing a inodilating effect, at reduced myocardial oxygen consumption energy expenditure when compared to other positive inotropic agents
as indicated by Fuentes, 2004 and Atkinson et al., 2009 which would explain the effect seen in the present study.
Temporary therapeutic measures include rapid fluid infusion, administration of positive inotropic agents
, and pericardiocentesis.
New positive inotropic agents
with higher safety margins and stronger effects on cardiac contractility have been introduced in human and veterinary cardiology during the last 20 years (3) and their use must be explored in the avian patient.