The results obtained from this investigation represents positive cooperativity
of comfarol with urease.
Palonosetron is a second generation 5-[HT.sub.3] receptor antagonist superior to other 5-[HT.sub.3] antagonists due to the allosteric binding and positive cooperativity
leading to a longer half-life (37 hrs.).
Hill's coefficient for hydrolysis in pH 10.0 and pH 11.0 was >1 indicating positive cooperativity
between the interacting sites.
In ligand-receptor binding kinetics, for example, the equation is strictly valid only for simultaneous binding of all ligand molecules; for the more likely sequential or independent binding schemes, it applies only for strong positive cooperativity
This remarkably high Hill coefficient may imply multiple HXT binding sites exhibiting positive cooperativity
When such binding occurs, a conformational change producing positive cooperativity
would increase the on-rate of the receptor binding to the fiber.