also reported fungal endarteritis of the ascending aorta by Bipolaris species following replacement of the aortic valve with a porcine valve
which ultimately resulted in the patient's death.
The patient's past medical history was significant for coronary artery disease with a history of coronary artery bypass graft, mitral valve replacement with a porcine valve
and graft, and atrial fibrillation.
This present report proposes a novel method for the specific quantification of any residual bile acids (cholate, deoxycholate, and taurodeoxycholate) entrapped in the ECM of porcine valve
scaffolds as in case of procedures [17, 19, 32, 33] already considered for clinical use or reported as significantly promising for the production of biocompatible cardiovascular substitutes [34, 35].
durability: A comparison between Hancock standard and Hancock II bioprostheses.
Minniti et al., "The fate of Hancock II porcine valve
recipients 25 years after implant," European Journal of Cardio-Thoracic Surgery, vol.
Examination of the extracted bioprosthetic valve revealed devitalized porcine valve
with rare mononuclear cells on the surface of the leaflets (Figure 1, A and B).
In several studies, by 15 years the porcine valve
has failed in 30 percent to 60 percent of patients.
typically fail suddenly and unpredictably by tearing.
and Haverich A., Tissue engineering of heart valves--Human endothelial cell seeding of detergent acellularised porcine valves
. European Journal of Cardio Thoracic Surgery 14(3): 279-284 (1998).
Second-generation pericardial valves are more durable than traditional porcine valves
as aortic valve replacements, said Guangqiang Gao, M.D., and associates at Providence Health System, Portland, Ore.
Mechanical valves appear to be superior to porcine valves
in patients undergoing mitral or aortic valve replacement, according to Dr.
are easily available, and not in fixed supply, as are human blood or human donor organs.