polyubiquitination


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polyubiquitination

The process of tagging proteins destined for degradation by attaching a chain of UBIQUITIN molecules to them. Such tagged proteins are then taken up by PROTEASOMES and enzymatically degraded to peptides.
References in periodicals archive ?
Background: The E3 ubiquitin ligase neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) negatively regulates phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein levels through polyubiquitination and proteolysis, but its significance in lung cancer is still unclear.
54-56) Both cIAPs-induced polyubiquitination and its accompany auto-phosphorylation and XIAP-induced polyubiquitination have been shown to be associated with RIP2 down-stream NF-kB activation, although the necessity for cIAPs-induced ubiquitination has been questioned by the fact that cIAP inhibitors do not abrogate RIP2 signaling function (see further discussion below).
31] latch motif, which are necessary for the interaction with Keap1, and a hydrophilic region of lysine residues, which are required for the Keap1-dependent polyubiquitination and degradation of Nrf2 (Taguchi et al.
Under a basal condition, NRF2 is sequestered in the cytoplasm and its expression is maintained to be low due to constant polyubiquitination.
This results in failure of polyubiquitination and proteasomal degradation of HIF, which is central for the pathogenesis of the disease.
Polyubiquitination is important to a variety of cellular functions.
Experiments performed with mutant ubiquitin showed a dramatic rescue of MHC I levels on the surface but no diminishment of poly-ubiquitination, suggesting that K5 can induce polyubiquitination at several different residues, but only polyubiquitin chains containing Lys11 and Lys63 linkages provide a signal for endocytosis [29].
Inducers of NF-[kappa]B act through intracellular signaling cascades that activate the I[kappa]B kinases (I KKs), which phosphorylate two specific N-terminal serines of I[kappa]Ba, resulting in I[kappa]Ba polyubiquitination and degradation in the 26S proteasome (57).
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling.
Another molecule, zinc mesoporphyrin (a synthetic heme analogue with a central zinc of the mesoporphyin macrocycle) causes a dramatic downregulation of the NS5A protein by enhancing its polyubiquitination and proteasome-dependent degradation.
It was shown that arsenic-induced PML SUMOylation triggers polyubiquitination and proteasome-dependent degradation [5].
Thermal acclimation and stress in the American lobster, Homarus americanus: equivalent temperature shifts elicit unique gene expression patterns for molecular chaperones and polyubiquitination.