Chilakamarri suspects that new drug therapies and
polytherapy are leading to movement effects.
If seizures continue despite the first initiated drug, it is necessary to increase the dose of the drug, change the drug, or switch to
polytherapy. Unal et al.
Variable Frequency % Duration of illness < 3 years 78 18.9 [greater than 334 81.1 or equal to] 3 years Antipsychotic yes 116 28.2
polytherapy No 296 71.8 Duration of treatment < 2 years 111 26.9 2-5 year 87 21.1 > 5 years 214 51.9 Type of antipsychotics FGA 250 60.7 SGA 46 11.2 FGA+FGA 96 23.3 FGA+SGA 19 4.6 FGA+FGA+SGA 1 0.2 Route of antipsychotics Oral 368 89.3 Injectable ([dagger]) 44 10.7 Number of admissions None 290 70.4 One 66 16.0 [greater than 56 13.6 or equal to] two EPS Yes 43 10.4 No 369 89.6 Drug adherence Yes 243 59.0 No 169 41.0 Substance use No 250 60.7 Yes 162 39.3 EPS, Extrapyramidal side effects; FGA, first generation antipsychotics; SGA, second generation antipsychotics.
CEO Marco Taglietti stated, "For patients dealing with multiple medical issues and
polytherapy, these data demonstrate SCY-078's potential as an alternative to current standards of care, especially when the standard of care is well known to cause clinically meaningful drug-drug interactions.
The reasons for medication non-adherent can include age, perception and duration of disease,
polytherapy, psychological factors, safety, tolerability and cost.
Polytherapy was required from the beginning in 15% of patients.
Polak, "Virtual clinical trial toward
polytherapy safety assessment: combination of physiologically based pharmacokinetic/pharmacodynamic-based modeling and simulation approach with drug-drug interactions involving terfenadine as an example," Journal of Pharmaceutical Sciences, vol.
Moreover, our patients were receiving various antithrombotic therapies, ranging from antiplatelet monotherapy to
polytherapy with concurrent heparin.
Children under
polytherapy have a higher risk of this adverse event [6].
Subjects undergoing
polytherapy tended to have AEs more than those undergoing monotherapy while epilepsy duration, seizure frequency, epilepsy type, epilepsy etiology and syndrome, numbers of AEDs, AEDs duration, type of AEDs, and comorbidity did not show any relation with AEs (Table 3).
Moreover, these patients often use AED
polytherapy and other drugs targeting the brain, which may cause pharmacodynamic interactions and further increase the risk of disturbed behavior [28, 115].