reported a new clinical entity in 10 patients (8 males & 2 females), who presented with acute onset symmetrical polysynovitis involving most of their appendicular joints and flexor digitorum tendons associated with pitting edema of the dorsum of both hands and both feet.
1] In RS3PE, the word synovitis is used, rather than arthritis because patients presents with symmetrical polysynovitis of joints.
In a study from France, where rituximab was used in 16 patients with pSS, it was found to be efficacious for systemic features, such as polysynovitis
, cutaneous vasculitis, and it also resulted in regression if not complete remission of associated lymphoma.
Concurrence of benign edematous polysynovitis
in the elderly (RS3PE syndrome) and endometrial adenocarcinoma.
Remitting, seronegative, symmetric synovitis with pitting edema syndrome is defined as seronegative symmetric polysynovitis
and arthritis of the distal limbs, primarily the wrist, MCP, PIP and ankle joints with acute onset, together with pitting edema on the dorsum of the hands and feet (1).
Clinically, they had a symmetrical polysynovitis
and flexor tenosynovitis of the distal joints.
In three anti-CCP-positive patients with polysynovitis
, the use of DMARDs [disease-modifying anti-rheumatic drugs] might have prevented progression to rheumatoid arthritis," they wrote.