polysorbates


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polysorbates

(pŏl″ē-sor′bāts)
Nonionic surface-active agents composed of polyoxyethylene esters of sorbitol. They usually contain associated fatty acids. The series includes polysorbates 20, 40, 60, and 80, which are used in preparing pharmaceuticals. These polysorbates have the trade names of Tween 20, Tween 40, and so forth.
References in periodicals archive ?
Polysorbate damage to biotherapeutics is discussed at length in a just published review article in the Journal of Excipients and Food Chemicals.
Polysorbate 60 and its close relatives, polysorbate 65 and polysorbate 80, work like mono- and diglycerides.
Key advantages of these products will be: all-natural, no preservatives (such as potassium sorbate or EDTA), no undeclared additives and only GRAS, clean label ingredients for direct food use (no polysorbates or hydrogenated castor oil PEG 40).
A universal-detection method for pharmaceutical manufacturing operations uses reverse-phase HPLC with the Corona CAD de tector for sensitive and robust analysis of polysorbates. It is suited for speciation of the various individual components of a non-ionic mixture and for batch-to-batch comparisons to measure variations in polysorbate composition from various sources or lots of material.
With 370 million pounds per year capacity, it will produce a broad range of non-ionic surfactants and specialty alkoxylates, such as kosher polysorbates, amine and alcohol ethoxylates, high molecular weight PEGs and much more.
There is no need for EDTA or preservatives, there are no detergents or polysorbates.
Comments:Tween polysorbates are surfactants which are formed by reacting 100% bio-based ethylene oxide with 100% bio-based sorbitan esters (Span USDA BioPreferred Certified 100% bio-based).
Super Refined[R] J.T.Baker[R] Polysorbate 20 and 80 are designed to improve solubilization and stability in a variety of biopharmaceutical and small-molecule drug formulations.
Avantor Performance Materials' Super Refined grade of polysorbate products improve solubilization and stability in a variety of biopharmaceutical and small-molecule drug formulations.