Cluster 1 Cluster 2 Cluster 3 Number of observations 1 9 18 Amplification 1/0/0 9/0/0 0/4/14 (amp/equiv/neg) Polysomy 0 0 3 GH by Cell_Amp_%_M 0 1 1 (by HER2/CEP17 ratio) GH by Cell_Amp_%_M 0 4 6 (by HER2 only) AshD_Ratio > 2 1 1 2 AshD_Her2 > 2 1 4 6 AshD_CEP17 > 2 1 0 5 Predominantly Amplified Amplified Negative Cluster 4 Total Number of observations 22 50 Amplification 3/17/2 50 (amp/equiv/neg) Polysomy 19 22 GH by Cell_Amp_%_M 6 8 (by HER2/CEP17 ratio) GH by Cell_Amp_%_M 17 27 (by HER2 only) AshD_Ratio > 2 1 5 AshD_Her2 > 2 12 23 AshD_CEP17 > 2 5 11 Equivocal Predominantly Polysomic
Bimodal Figure 4: Examples of the tumor cases from the clusters extracted from the automated HER2 FISH data.
One of these polysomic
cases also had trisomy 7 (Figure 2, A and B).
segregation, temperature sensitivity, a range of genetic expression levels, and a high potential for genetic polymorphisms combine to create a relatively high level of phenotypic instability for the nonflowering trait.
7 8 9 10 OLYMPIC +A= MYOPICAL +B= AMBLYOPIC +L= COMPLIABLY< +T= COMPATIBLY< +D= DIPLOMACY +I= OLYMPIADIC< +E= POLYAEMIC +H= POLYHAEMIC +E= POLYEMIC +A= polyaemic> +R= POLYMERIC +F= CLYPEIFORM +T= LIPECTOMY +I= TIME POLICY< +X= COMPLEXITY< +I= IMPOLICY +S= MISPOLICY< +S= OLYMPICS +C= CYCLOPISM< +I= mispolicy> +O= POLYSOMIC
+E= POLYOECISM 11 +T= MYELOPATHIC +O= +Y= +S= CYPSELIFORM< +T= COMPOSITELY<
The statistical association between Cep17 copy number, categorized as polysomic
or eusomic, and ER, PgR, and Ki-67 expression, age, lymph node status, and histologic grade was assessed by using the x2 test.
polyploidy, selfing, outcrossing, and asexual reproduction by tubers.
(54) Patients with chromosome 17 polysomic
breast cancer in the absence of HER2 amplification or 3+ IHC are not candidates for targeted therapy, and they have not been considered eligible for adjuvant trastuzumab trials or trials comparing different HER2 therapies.
The commonly grown form of smooth bromegrass is a polysomic
octoploid, 2n = 8x = 56, with a genome structure of AAAA[B.sub.1][B.sub.1][B.sub.2][B.sub.2] (Ghosh and Knowles, 1964; Armstrong, 1980, 1992).
Mapping genetic markers in a polysomic
species like L.
These observations seem to indicate that either both tetraploids and octaploids are disomic polyploids or that they are polysomic
polyploids under strong selection for bivalent pairing.
Use of haploids and isozyme markers for genetic analysis in the polysomic
Of the species listed, none is a diploid, and most are characterized by polysomic