Previous phylogenetic studies using a fragment of the structural polyprotein
open reading frame suggest that MAYV occurs in 2 distinct genotypes, D and L (6).
2 List of Figures Figure 1: HCV Genome and Polyprotein
Composition 22 Figure 2: HCV Lifecycle Overview 23 Figure 3: 9MM, Prevalent Cases of HCV, Ages?
The ORF encodes a precursor polyprotein
that is proteolytically cleaved to form the functional protein products.
In their study, the researchers focused on an HIV polyprotein
called Gag, which is made up of several proteins that together are 500 amino acids long.
The HIV life cycle offers several such targets: 1) binding of virus to host cell, 2) transcription of RNA to DNA, 3) integration of viral DNA into host genome, and 4) protease segmentation of viral polyprotein
One plasmid expressed a polyprotein
designated Grttn, consisting of translational fusions of HIV-1 subtype C Gag, reverse transcriptase, Tat and Nef.
N-terminal analysis has revealed the margins of the capsid proteins and the corresponding scissile bonds within the structural polyprotein
(Valles and Hashimoto 2008).
Computer-assisted assignment of functional domains in the nonstructural polyprotein
of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
galli and the ES products of mature worms were analysed and the host specific fatty acid-binding proteins (FABPs), a member of the nematode polyprotein
allergen family were reported .
HIV-1 protease is expressed within the Gag-Pol polyprotein
(Kramer et al.
3 provirus ancestral Env polyprotein
32 Hippocalcin-like protein 1 (Visinin-like protein 3) (VILIP-3) 33 Non-muscle caldesmon 43 Annexin A5 (Annexin V) (Lipocortin V) (Endonexin II) 44 Calpain small subunit 1 (CSS1) 48 Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) 49 60 kDa heat shock protein, mitochondrial precursor (Hsp60) 57 Prolyl 4-hydroxylase alpha-2 subunit precursor (EC 1.
The 5'- and the 3'-NTRs of the genome are highly conserved and contain control elements for translation of the viral polyprotein