NS5A represents a 447 aa polyprotein
containing three distinct domains: 1 (aa 1-213), 2 (250-342), and 3 (356-447) (Figure 1(a)) .
IgG, IgM and IgA antibodies against the novel polyprotein
in active tuberculosis.
Evaluation of recombinant Leishmania polyprotein
plus glucopyranosyl lipid A stable emulsion vaccines against sand fly transmitted Leishmania major in C57BL/6 mice.
The suggested map of the PRSV polyprotein
is outlined in Figure 1.
Segment A contains two open reading frames (ORF), the largest one is translated into a polyprotein
which includes the major protein of the viral capsid (VP2).
It possessed a single long ORF of 6684 nucleotides encoding the polyprotein
of 2228 aa.
The well known immunosuppressive agent cyclosporin A was originally proposed to suppress HIV-1 replication by interference with the binding of cyclophilin A to the viral Gag polyprotein
Segment A encodes a polyprotein
that can be cleaved by auto proteolysis to form mature viral proteins VP2, VP3 and VP4 .
Its overall genome organization is typical of other coronaviruses, with five major open reading frames (ORFs) encoding the replicase polyprotein
, which comprises two-thirds of the genome, and the four major structural proteins.
2D); and clone RSG10-U showed some similarity (37% identities) to a polyprotein
(i.e., reverse transcriptase) of Sorghum bicolor (L.) Moench (AAD22158, Fig.
We performed phylogenetic analyses on this virus and all complete rhinovirus polyprotein
genes available in the GenBank database.
The M segment comprises a single ORF which encodes a large polyprotein
that is cleaved during or after the translation and produces a nonstructural protein (NSm), and two structural surface glycoproteins (Gn and Gc) .