polyprotein

polyprotein

(pŏl′ĭ -prō′tēn”) [″ + ″]
A polypeptide that contains the linked transcripts of several proteins. Cleavage of the polypeptide releases the contained protein sequences.

polyprotein

A large gene product that is split into two or more independent proteins.
References in periodicals archive ?
ORF1 encodes a single polyprotein that is cleaved by the viral protease into 7 nonstructural proteins and the major capsid protein, viral protein (VP) 60, whereas ORF2 encodes a minor structural protein, VP10 (Figure 1) (1).
These antibodies production is due to cross reactive immune reactions between epitopes on the viral polyprotein which has resemblance with human antigen and human proteins promoting inflammation and tissue injury8.
Mutation significantly activated the expressions of a retrovirusrelated Pol polyprotein from transposon TNT gene (T3-9216, Figure 2f); a bidirectional sugar transporter gene (T2-48565, Figure 2g); and a probable mixedlinked glucan synthase gene (T4-58749, Figure 2h).
Upon infection, the internal ribosome entry site element in the 5'-untranslated region drives the translation of the viral processor polyprotein (29).
The non-structural polyprotein 3ABC of Foot-and-mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle.
A study using FL-N/35 transgenic mice harboring the HCV polyprotein also found decreased hepcidin expression in the liver, accompanied by an increase in FPN expression in the duodenum, spleen, and liver.
It has a positive-sense RNA genome that is translated as a single polyprotein and post-translationally cleaved into three structural proteins and seven nonstructural proteins (Henchal & Putnak, 1990).
The genomic RNA is translated into a single polyprotein precursor consisting of three structural Capsid (C), perinuclear membrane (prM), and Envelop (E) protein and seven non-structural NS1, NS2a, N S2b, NS3, NS4a, NS4b and NS5 proteins arranged in the order C-prM-E-NS1-NS2a-NS2b-NS3-NS4a-NS4b-NS5.
Other MAG/ED-specific genes sequences of <500 bp or less then 100-fold expressed compared with other tissues were also identified, such as oocyte maturation arresting factor (Unigene21945), antigen 5 precursor (Unigene21744), N-acetylgalactos-aminyltransferase (Unigene22691), reverse transcriptase polyprotein (Unigene 21663), and potassium-dependent sodium--calcium exchanger (Unigene21750).
Synthesis of infectious pancreatic necrosis virus polyprotein, detection of a virus-encoded protease, and fine structure mapping of genome segment A coding regions.
The polyprotein chain that is translated from this open reading frame is cleaved to generate the individual viral proteins.