Ginkgo biloba extract (GBE) contains terpenoids, flavonoids, alkylphenols, polyprenols
, and organic acids.
neuroprotection, unsaturated cytotoxicity against polyprenols
, a number of human cembranoids, cancer cell lines, a diterpenes nti-H IV activity Mimosa tenuiflora anti-inflammatory, tannins and Willd.
Carroll, "Distribution, metabolism and function of dolichol and polyprenols
," Progress in Lipid Research, vol.
It is isolated from the neutral fraction of an extract of spruce needles and belongs to the group of polyprenols: polyisoprenoid alcohols that are transformed into dolichols in the liver (Blogger et al.
The extraction and purification of Ropren [R] substance (polyprenols) for use in finished products to be administered to animals have been described (Vasiliev et al.
The proton NMR spectrum of Ropren [R] substance is in accord with the published data for betulaprenol type polyprenols (lbata etal.
Ropren[R] is a novel plant preparation, which belongs to the group of polyprenols: long chain polyisoprene alcohols (Blogger et al.
In a review of chemical analysis of GB leaves and extracts, important constituents are present in the medicinally used leaves: terpene trilactones, i.e., ginkgolides A, B, C, J and sesquiterpene bilobalide, many flavonol glycosides, biflavones (bilobetin, ginkgetin, isoginkgetin, amentoflavone and sciadopitysin), proanthocyanidins, alkyphenols, simple phenolic acids, 6-hydroxykynurenic acid, 4-O-methylpyridoxine and polyprenols
Keywords: Coccinia grandis; Polyprenols; Antidyslipidemia; Hamster model
The polyprenols, which were isolated from chloroform fraction, showed antidyslipidemic activity.
The ethanolic extract, its fractions and the polyprenols did not alter significantly the food intake or body weight in all the above experiments.
In point of fact, dolichol derivatives, mixture of polyprenols
(acyclic isoprenoid alcohols) known as Ropren (Solagran Limited, Melbourne, Australia) commercially used to treat liver diseases, were tested in the treatment of AD in two separate trials conducted in 2005 and 2006 with promising results [http://www.asx.com.au/asxpdf/20071119/ pdf/315x5nh4hm8wv7.pdf, http://www.asx.com.au/asxpdf/ 20070221/pdf/3111ztwcbqzkk9.pdf].