In point of fact, dolichol derivatives, mixture of polyprenols
(acyclic isoprenoid alcohols) known as Ropren (Solagran Limited, Melbourne, Australia) commercially used to treat liver diseases, were tested in the treatment of AD in two separate trials conducted in 2005 and 2006 with promising results [http://www.
neuroprotection, unsaturated cytotoxicity against polyprenols
, a number of human cembranoids, cancer cell lines, a diterpenes nti-H IV activity Mimosa tenuiflora anti-inflammatory, tannins and Willd.
Polyprenols can be extracted from the green verdure of various conifer and non-conifer species.
The proton NMR spectrum of Ropren [R] substance is in accord with the published data for betulaprenol type polyprenols (lbata etal.
Long chain betulaprenol type polyprenols from the leaves of Gingko biloba.
A comparative study of the effect of the polyprenol preparation ropren from coniferous plants on the key enzymes of the cholinergic and monoaminergic types of nervous transmission.
ginkgolides A, B, C, J and sesquiterpene bilobalide, many flavonol glycosides, biflavones (bilobetin, ginkgetin, isoginkgetin, amentoflavone and sciadopitysin), proanthocyanidins, alkyphenols, simple phenolic acids, 6-hydroxykynurenic acid, 4-O-methylpyridoxine and polyprenols
In HFD-fed hamsters treatment with polyprenols for 7 days orally resulted in significant lowering in TG and TC.
The ethanolic extract, its fractions and the polyprenols did not alter significantly the food intake or body weight in all the above experiments.
Finally, on the basis of the above results it can be concluded that the polyprenols showed significant potential to lower the level of plasma lipid profile followed by a beneficial effect on HDL and its ratio with total cholesterol, in dyslipidemic hamster model, may further be optimized for development of antidyslipidemic drug.
Chloroform-soluble fraction containing active component was subjected to repeated column chromatography, furnished a polyprenol characterized as [C.
8 kg, 230-400 meshes) with benzene as eluent, and gave a polyprenol fraction (16.