Adenomatous polyposis coli
truncation mutations in 2-amino-1-methyl-6-phenylimidazol 4,5b pyridine (PhIP)-induced intestinal tumours of multiple intestinal neoplasia mice.
Toyota et al., "Analysis of adenomatous polyposis coli
promoter hypermethylation in human cancer," Cancer Research, vol.
Sporadic intra-abdominal tumors occur much less frequently when compared to intra-abdominal desmoid tumors associated with familial polyposis coli
. Most sporadic tumors are extra-abdominal in location.
Desmoid tumour biology in patients with familial adenomatous polyposis coli
. Br J Surg 2013;100(5):694-703.
Although many questions are yet to be answered when it comes to diagnosis, counseling, and screening/therapeutic strategies for patient with MUTYH mutations, it has been receiving increased attention in those patients presenting with polyposis coli
and colorectal cancers.
Panariello et al., "Familial adenomatous polyposis coli
: five novel mutations in exon 15 of the adenomatous polyposis coli
(APC) gene in Italian patients.
Hinchman et al., "Adenomatous polyposis coli
(APC)-independent regulation of [beta]-catenin degradation via a retinoid X receptor-mediated pathway," Journal of Biological Chemistry, vol.
Identification and characterization of the familial adenomatous polyposis coli
Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli
- Familial Adenomatous Polyposis Coli
Global Clinical Trials Review, H2, 2015
[USPRwire, Wed Sep 23 2015] GlobalData's clinical trial report, "Familial Adenomatous Polyposis Coli
Global Clinical Trials Review, H2, 2015" provides an overview of Familial Adenomatous Polyposis Coli
clinical trials scenario.
Mutations of adenomatous polyposis coli
(APC) gene are uncommon in sporadic desmoidtumours.