The results of the clinical trial, published in The Lancet, demonstrate for the first time the effectiveness of a fixed-dose combination pill for preventing cardiovascular disease (heart disease and stroke) and indicate that the benefits of widespread polypill
use outweigh any known side effects.
The research claims that, when compared with just receiving lifestyle advice, those who took the polypill
reduced their risk of major cardiovascular disease by 34%.
The second group, containing 3,421 people, was given the same advice, but were also required to take a polypill
led to large reductions in bad cholesterol but had only a slight effect on blood pressure, the study showed.
in the study contained two common blood pressure drugs, a cholesterol-lowering statin and aspirin, the researchers said.
Gholamreza Roshandel, Ph.D., from Shariati Hospital in Tehran, Iran, and colleagues assessed the effectiveness and safety of a four-component polypill
, including aspirin, atorvastatin, hydrochlorothiazide, and enalapril or valsartan, for the prevention of cardiovascular disease in a cohort study including participants of the PolyIran study aged 40 to 75 years from the Golestan province, Iran.
The Fuster--CMC--Ferrer Cardiovascular polypill
Speaking at the annual meeting of the American College of Cardiology, Ruth Webster, PhD, said that the tested polypill
contained half the standard doses of the angiotensin receptor blocker telmisartan (20 mg), the calcium channel blocker amlodipine (2.5 mg), and the diuretic chlorthalidone (12.5 mg).
Summary: TEHRAN (FNA)- Iranian researchers have produced a new type of medicine named 'Polypill
' which helps reduction of premature death resulting from heart attack and stroke.
Hopefully, our local drug manufacturers can duplicate what India has done by manufacturing a 'polypill
,' a single capsule or tablet containing all these essential drugs.
Srinath Reddy, "Strengths and limitations of using the polypill
in cardiovascular prevention," Current Cardiology Reports, vol.