The lesion has mainly two forms; monostotic form defines single bone involvement and polyostotic
form defines multiple bone involvement.
Characteristic phenotypic features such as short stature, obesity, round face, low nasal bridge, shortened metacarpals, shortness and thickness in distal phalanges, subcutaneous calcifications, polyostotic
fibrous dysplasia, developmental delay, and besides, mental retardation can be observed in these patients (1,7).
Classically, McCune-Albright syndrome (MAS) is characterized by cafe-au-lait macules, polyostotic
fibrous dysplasia and multiple endocrinopathies, including precocious puberty.
Lastly, this study did not directly evaluate the potential influence of reproductive status on specimen bone density (ie, polyostotic
form, accounts for 70-80% of cases, while the polyostotic
It is a developmental anomaly which may occur in a monostotic or polyostotic
form.28,29 It can involve any part of bone, including epiphysis, metaphysis or diaphysis, and may present associated with other abnormalities like intramuscular myxoma, skin pigmentation, sexual precocity and thyroid abnormalities.
The mainly forms of fibrous dysplasia are monostotic form (70-80% of cases) with one bone involvement and polyostotic
form with several bones involvement (6,7).
Although it is most frequently monoostotic, it can be polyostotic
in 25-34% of patients.
fibrous dysplasia evaluated for malignant transformation with 99mTc-MDP bone scan and [.sup.18]F-FDG PET/CT.
FD can be classified into 2 types: monostotic, involving a single bone, and polyostotic
, consisting of multiple lesions in different bones (1).
For 12 years, Emanuel Zayas battled a medical condition called polyostotic
fibrous dysplacia, an illness which causes developmentally certain bones to become soft.
Zayas developed the massive tumor that almost covered his face after suffering from a rare disease called polyostotic
fibrous dysplasia - a genetic disorder in which fibrous tissue begins to replace the bone in the body.