polymyxins


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Related to polymyxins: colistin, Sulfonamides, Polyenes

polymyxins

A group of five POLYPEPTIDE antibiotic drugs active against various GRAM NEGATIVE bacteria. They are used almost exclusively as external applications in ointments and eye and ear drops because of their toxicity if taken internally.
References in periodicals archive ?
MicuRx added that its new agent MRX-8 is designed to overcome the limiting nephrotoxicity of current polymyxins.
Polymyxins displayed strong activity against Enterobacteriaceae, with susceptibility rates of>90%, except for E.
At this time, CDC recommends that Enterobacteriaceae isolates with a colistin or polymyxin B MIC >4 ftg/ml be tested for the presence of mcr-1; testing is available through CDC (5).
Adverse reactions associated with systemic polymyxin therapy.
Antimicrobial susceptibility, Intensive care unit, Polymyxin B.
Aleksandar Danilovski, said, "As the world's leading supplier of both polymyxin B and colistin, Xellia has the experience and capability to develop new, polymyxin-like drugs with less side-effects.
14,15) Resistance to polymyxins has also been reported by many authors (12,16) but in our study we did not notice any resistance to these antibiotic.
territories, and Canada said they had treated at least one MDR-GNB infection resistant to all antimicrobials tested except polymyxins in the previous 12 months.
In order to deal with such situation Tigecycline, polymyxins (colistin and polymyxinB) and Fosfomycin are considered possible candidate therapies for infections caused by CPE.