polymorphous low-grade adenocarcinoma


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

polymorphous low-grade adenocarcinoma

A low-grade carcinoma of older patients that affects minor salivary glands, especially the palate (where 60% of PLGAs occur), far less often than major salivary and nasopharyngeal glands.

Management
Excision, post-operative radiation therapy.

Prognosis
Good; recurrence, 12%; local extension, 10%.
References in periodicals archive ?
Application of alpha-smooth muscle actin and c-kit in the differential diagnosis of adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma.
Mixed tumor, polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: pathogenic implications and differential diagnosis by Ki-67 (MIB1), BCL2, and S-100 immunohistochemistry.
Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma.
Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.
C-kit expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and monomorphic adenoma.
Polymorphous low-grade adenocarcinoma of minor salivary glands: a study of 17 cases with emphasis on cell differentiation.
Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas.
Polymorphous low-grade adenocarcinoma versus pleomorphic adenoma of minor salivary glands: resolution of a diagnostic dilemma by immunohistochemical analysis with glial fibrillary acidic protein.
The Differentiation of Adenoid Cystic Carcinoma, Polymorphous Low-Grade Adenocarcinoma, and Pleomorphic Adenoma c-KIT Calponin/SMA/SMMHC CK7 MIB-1 AdCC + + +, luminal cells >10% PLGA - or + - or +, focal +, all cells <5% PA - or + + +, luminal cells <5% Myb PLGA1 GFAP AdCC + or - - - PLGA - - - PA - + + Abbreviations: AdCC, adenoid cystic carcinoma; CK, cytokeratin; GFAP, glial fibrillary acidic protein; PA, pleomorphic adenoma; PLGA, polymorphous low-grade adenocarcinoma; SMA, smooth muscle actin; SMMHC, smooth muscle myosin heavy chain.
The following year, Evans and Batsakis used the term polymorphous low-grade adenocarcinoma to describe this malignancy as a clinically and pathologically discrete entity.
The differential diagnoses that we considered included polymorphous low-grade adenocarcinoma, primary or metastatic papillary thyroid carcinoma, and adenoid cystic carcinoma.
Among them are polymorphous low-grade adenocarcinomas, lobular carcinomas, terminal duct carcinomas, and low-grade papillary adenocarcinomas.