This article will summarize the pathophysiology of polymicrogyria and its definition, causes, and clinical manifestations; typical patient management issues; and the need for collaborative healthcare.
Polymicrogyria is characterized by abnormal fetal cortical development which results in many small gyri with shallow sulci and abnormal cortical layering (Villard et al.
There are numerous syndromes and patterns of polymicrogyria, and many have been shown to correspond with chromosomal abnormalities (Figure 22).
The imaging appearance can vary from wide Sylvian fissures, thickening of the cortex, localized polymicrogyria of the insula, and thickened or shallow gyri and they may be accompanied by anomalous vessels.
Based on the findings of the published reports, it appears three patterns of abnormalities are associated with maternal parvovirus B19 infection: positional limb deformities, radiographic evidence of intercranial calcifications, and dysplastic changes, including agyria, macrogyria, polymicrogyria
, and dysgenesis of the corpus callosum, he said.
Blisse has polymicrogyria
and periventricular nodular heterotopia which both affect the way the brain grows.
Good friend James Sullivan, a fellow EMT, had a daughter, Brenya, who was born in March 2009 with polymicrogyria
, a serious brain malformation.
Little Josef was born with polymicrogyria
, affecting the left side of his body with cerebral palsy, leaving him profoundly deaf and unable to walk without a frame.
But, he said, it wasn't until a close friend's daughter, Brenya, was born with a serious brain malformation called polymicrogyria
that he was fully exposed to the services provided at Children's.
Josef, who will be two on Sunday, has polymicrogyria
, a condition which can affect one or both sides of the brain, and has left him unable to walk or stand on his own two feet unaided.
Tests then revealed he had polymicrogyria
, a condition which means the brain does not form properly.
Little blondie, Josef, has polymicrogyria
, a condition which can affect one or both sides of the brain, and has left him unable to walk unaided or stand on his own two feet.