6 The process identifies all the clinically relevant rifampicin resistance inducing mutations in the RNA polymerase beta
(rpoB) gene in the mycobacterium tuberculosis genome in a real time format using fluorescent probes called molecular beacons.
This study was conducted to examine whether the association of a proliferation-inducing ligand (APRIL), spermatogenesis associated 8 (SPATA8), platelet-derived growth factor receptor-alpha (PDGFRA), and DNA polymerase beta (POLB) with SLE can be replicated in a Chinese Han population.
DNA polymerase beta gene mutation in human breast cancer.
Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.
XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP- ribose) polymerase, and DNA ligase III is a novel molecular nick-sensor' in vitro.
Consequently, analysis of internal transcribed spacer 1 (ITS1) region and two important genes named RNA polymerase II largest subunit (RPOIILS) and the mitochondrial DNA polymerase beta (DPOLB), encoding critical biologic functional proteins in kinetoplastida were performed.
Similarly, primers were designed for DNA polymerase beta (LmjF08.
This activity was previously demonstrated in polymerase beta
, which is active in a repair pathway called base excision repair (BER).
While working with Klaus Rajewsky at the University of Cologne in Germany, Gu and his colleagues wanted to know how an enzyme called polymerase beta affected the function and development of white cells.
One parent strain carried functional polymerase beta genes sandwiched between two 34-base-pair bits.
Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair.
Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage.