In addition to increase in the thickness of the corneal epithelial basement membrane, corneal morphological changes include polymorphism, polymegethism
, irregular cellular distribution and stunting of surface cell microvilli6,7.
Duration of DM was significantly correlated with type of DR (r = 0.545, p < 0.01), HbA1c level (r =0.165, p = 0.044), CED (r = - 0.282, p <0.01), polymegethism (r = 0.276, p =0.001) and hexagonality (r = 0.162, p = 0.048).
In our study, duration of DM showed significant correlation with type of DR, HbA1c level, CED, polymegethism and polymorphism.
Thus, conventional hydrogel lenses with low oxygen permeability (Dk) may cause hypoxic condition of the cornea and can further lead to clinical issues such as corneal edema, corneal neovascularization, corneal acidosis, epithelial keratitis, and endothelial polymegethism .
Therefore, it is important to estimate the Dk during SCL wear because decreased Dk will cause side effects such as corneal edema, corneal striae, corneal folds, endothelial polymegethism, and corneal exhaustion syndrome [4,6].
Apparent Descemet's folds have been found in 8.3% of the KC cases associated with pleomorphism (variation in shape) or polymegethism
(variation in size) of endothelial cells .
The coefficient of variation represents the degree of variation in cell size also known as polymegethism .
Histopathological analysis of corneal endothelial polymegethism. Cornea.
Practitioners know that corneal metabolism suffers if there is not enough oxygen supply: microcysts, polymegethism
, weakened tight epithelial junctions and new vessel growth are just some of the clinical manifestations.
In addition to the endothelial cell density, polymegethism
(CV), and polygonality (HEX) were also important parameters of the corneal endothelium which had been used as the index of the extent of variation in cell area and in cell shape.