poly(glutamic acid)

(redirected from polyglutamate)

pol·y(glu·tam·ic ac·id)

(pol'ē-glū-tam'ik as'id),
A polymer of glutamic acid residues in the usual peptide linkage (α-carboxyl to α-amino). See: poly- (2).
See also: poly (γ-glutamic acid).
Synonym(s): polyglutamate
References in periodicals archive ?
Folic polyglutamate, the principal dietary form of folate, consists of folic acid bound to one to six glutamic acid residues in a gamma peptide linkage.
The AR has a transactivation domain which is susceptible to two forms of polymorphism: a CAG repeat polymorphism which encodes a polyglutamate tract and a GGC repeat which encodes a polyglycine tract.
After being transported into the cytoplasm, through the reduced folate carrier, methotrexate is converted into intracellular polyglutamates. The polyglutamate forms ensure the intracellular retention of methotrexate, allowing weekly administration despite the relatively short plasma elimination half-life (5-8 hours) [72].
Folate occurs naturally in certain foods as a polyglutamate, a chain of glutamic acid (Pitkin, 2007).
Van Haandel et al., "The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response," Arthritis and Rheumatism, vol.
In the red cell, methyltetrahydrofolate exists highly concentrated almost exclusively as polyglutamate. It has been suggested that plasmodium cannot use this large store of reduced folate because of lack of the enzyme glutamylhydrolase to remove the polyglutamate moieties [7].
Contribution of common polymorphisms in reduced folatecarrier and glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis.
OPAXIO (paclitaxel poliglumex, CT-2103), which was formerly known as XYOTAX, is an investigational, biologically enhanced, chemotherapeutic that links paclitaxel, the active ingredient in Taxol, to a biodegradable polyglutamate polymer, which results in a new chemical entity.
XYOTAX (Zi-o-taks) is a biologically-enhanced chemotherapeutic that links paclitaxel, the active ingredient in Taxol, to a biodegradable polyglutamate polymer, resulting in a new chemical entity.
After introducing the basics of the use of infrahuman animal models for studying human psychiatric disease, they present current research on transgenic and knockout models leading to the analysis of neurocognitive dysfunction, including polyglutamate disorders, mental retardation, speech and language dysfunction, and autism.
For example, tRNAs could have, with equal plausibility, arisen in the context of a primitive translation apparatus for the preparation of non-catalytic peptides, such as the polyglutamate tails of folate cofactors.