genetic disorder

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Related to polygenic disorder: Autosomal disease, multifactorial disease

genetic disorder

A pathological condition caused by an absent or defective gene or by a chromosomal aberration. Also called hereditary disease.

ge·net·ic dis·or·der

(jĕ-net'ik dis-ōr'dĕr)
A widely used but nonetheless imprecise term that denotes a condition or illness related to biologic inheritance.

Patient discussion about genetic disorder

Q. what makes Arthritis a genetic disease?

A. First of all, the term arthritis is a bit inaccurate: Arthritis denotes an inflammation of joints. There are many kinds of arthritis that may result from different causes, and therefore, are different diseases: septic arthritis (inflammation due to infection of joint) has much less genetic background than ankylosing spondylitis (an arthritis of the lower back joints that occurs almost exclusively in people with certain genetic background).

The arthritis with the genetic background are usually the autoimmune ones: Due to genetic determinants, the immune system of some people is programmed to recognize the various parts of the joints (and other organs as well) as foreign (i.e. like bacteria) and thus launches an attack on them. In normal immune system, that doesn't happen.

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Q. Is bipolar disease a hereditary problem? My only son is in his teens that is the age to enjoy life, but he cannot enjoy his life with his friends because we found that he is suffering from a bipolar condition. I feel so sad for him and though my care-free days have gone, I often think about how much fun I had at his age. I too suffered from a bipolar disorder and my mom too. Is bipolar disease a hereditary problem? I want him to help to enjoy his life.

A. I agree with you. No one should suffer because of hereditary problems. This is the same situation here as genes are passed from generation to generation. This information is inconclusive because many who may have had bipolar disorders did not have it checked out. Who is to say, how many people 50 years ago had it but dismissed it as being moody, or ill tempered. Doctors were not aware about this problem years ago. Some time back, someone who showed signs of a mental disorder was straight away shoved into a mental hospital and left to suffer. Besides they are often treated with electric shock therapy eventually getting out of control. Testing is still in progress to find out if genetics play a role but these theories may take several more years before they can have a better understanding.

Q. Is FMS heredetery? My mother was diagnosed with FMS and I would like to know what are the chances I’ll have it too.

A. Hereditary is not the right term. It’s not a genetic disease but The cause of fibromyalgia remains elusive. However, recent studies show that genetic factors can predispose individuals to a genetic susceptibility to fibromyalgia.

More discussions about genetic disorder
References in periodicals archive ?
A: It is going to help, but being a polygenic disorder, it is going to be very difficult.
In polygenic disorders, many genes collectively contribute to the disorder.
It is this reputation of the antioxidants in the mainstream of pharmaceutical research that has attracted the scientific community and increased the popularity as an alternative new generation therapeutic approach for the management of diverse polygenic disorders of humans (Tiwari 2004).
Antioxidants: New-generation therapeutic base for treatment of polygenic disorders. Curr Sci 86;1092-1102.
We do not know exactly how many genes are involved in the polygenic disorders such as NTD, which has a multifactorial etiology (1), but their pathomechanism may be elucidated by analysis of genome-wide fetal gene expression.
The observed differences in gene expression in NTD suggest that this technology might be useful for elucidating the complex genetic background of polygenic disorders in the living human fetus.
A type 2 diabetic phenotype can develop in individuals with normal insulin sensitivity who have a monogenic defect that impairs (3-cell function (5) (Table 2) or in individuals who have any one of many polygenic disorders in which obesity, insulin resistance, and impaired [beta]-cell insulin secretory function are part of the altered metabolic state.