We provide an evidence that quantitative traits that may be controlled by polygenes
and a single gene or mutation may lead to a host of alterations in multiple traits.
(25), that patients with a clinical diagnosis of FH but with no identified mutation (FH/M-) have a significantly higher mean LDL-C-raising SNP score than individuals from the general population (combined sample P < 2.2 X [10.sup.-16]), which suggests that their high plasma LDL-C concentrations are considerably influenced by polygenes
. In addition, as previously reported, FH patients who carry an FH-causing mutation (FH/M+) also had higher mean LDL-C SNP scores than the WHII cohort (P = 0.04), which confirms results from Talmud et al.
in diploid alfalfa thataffect resistance to downy mildew.
SOLAR incorporates the information contained in the participants' pedigrees to obtain maximum likelihood estimates for the proportion of unexplained variance due to additive genetic effects from polygenes
and the proportion of variance due to unmeasured environmental covariates, measurement error and non-additive genetic effects.
Each phenotype has revealed different patterns of inheritance such as two-allele gene with co-dominant inheritance (7,8), oligogenic or polygenic model (9-11), recessive (12), two locus recessive13, mixed with recessive inheritance (14), and single locus with contribution for polygenes
(15) although some studies have failed to demonstrate any autosomal patterns of inheritance (7).
. Annual Review of Genetics, New York, v.27, p.205-233, 1993.
For this purpose, no molecular data are used, the aim being to test hypotheses about whether one or more major genes and/or polygenes
can account for the observed pattern of familial aggregation, the mode of inheritance, and to estimate the parameters of the best-fitting genetic model [Thomas, 2004].
This suggests the possible overlap between the polygenes
responsible for inheritance of type and function.
adaptedness and radiation (e.g., linkage, pleiotropism, polygenes
Absence of the third molar is common and is thought to be controlled by polygenes
. It has been reported as both autosomal dominant and autosomal recessive.