Gary-Bobo, "Differences in the interaction of the polyene antibiotic
amphotericin B with cholesterol- or ergosterol-containing phospholipid vesicles.
Amp B a polyene antibiotic
is the second line treatment for leishmaniasis, binds specifically to ergosterol, the main sterol present of Leishmania, trypanosome cruzi and fungi .
In the early part of the 20th century gentian violet, an aniline dye was use to treat fungus, but because of resistance and side effects, it was replaced by a polyene antibiotic
, and nystatin, was discovered in 1951.
It does not occur with Filipin, another polyene antibiotic.
Self-association of the polyene antibiotic nystatin in dipalmitoylphosphatidylcholine vesicles: a time-resolved fluorescence study.
Nystatin is a widely used polyene antibiotic
because it is very active against most pathogenic fungi such as Candida and Aspergillus.
Structure-Antifungal Activity Relationships of Polyene Antibiotics
of the Amphotericin B Group.
The polyene antibiotics, which apparently act by binding to membrane sterols, contain a rigid hydrophobic center and a flexible hydrophilic section.
Although numerous polyene antibiotics have been isolated, only amphotericin B is used systemically.
A major group of drugs that have been approved for the therapy of systemic fungal infections are polyene antibiotics
. Amphotericin B (AmB), one of the pofyene antibiotics, has been used to treat serious systemic fungal infections by binding to sterols such as ergosterol in fungal cells membrane, and is believed to form pores in the membrane and create a transmembrane ion-channel.
Ergosterol is the site of interaction for polyene antibiotics
while azoles interfere with ergosterol synthesis.