Phosphatidylcholine is one of the best-selling hepatoprotective drugs to hospitals.
Systemic Antifungal Agents in Invasive Fungal Infections That Act on Fungal Cell Membranes: Polyenes
Gary-Bobo, "Differences in the interaction of the polyene
antibiotic amphotericin B with cholesterol- or ergosterol-containing phospholipid vesicles.
In addition to the polyene
index, the ratio of linoleic-to-palmitic fatty acids (i.e., C18:2-to-C16:0) can serve as a reliable indicator of deterioration degree in polyunsaturated fatty acids .
Structure-Antifungal Activity Relationships of Polyene
Antibiotics of the Amphotericin B Group.
AmB (fungizone), a polyene
antifungal, is an amphipathic fermentation product of the Gram-positive bacterium, first isolated from Streptomyces nodosus in 1955.
AmB belongs to the polyene
class of antifungals and induces fungal cell death through apoptotic and nonapoptotic pathways [26-29].
Natamycin (E 235) is a tetraene polyene
macrolide and has amphoteric structure like other macrolides.
MacElroy, "A TD-DFT study of the effects of structural variations on the photochemistry of polyene
dyes," Chemical Science, vol.
glabrata strains (9.9%) were likely to be resistant to AMB as follows: five strains exhibited MIC of 2 [micro] g/mL, one strain presented MIC of 4 [micro] g/mL, and three strains exhibited MIC of 8 [micro]g/ml to this polyene
Most of the latter patients received conventional liver-protecting treatment, for instance, polyene
Amp B a polyene
antibiotic is the second line treatment for leishmaniasis, binds specifically to ergosterol, the main sterol present of Leishmania, trypanosome cruzi and fungi .