polyendocrine

polyendocrine

 [pol″e-en´do-krin]
pertaining to several endocrine glands.
polyendocrine autoimmune disease the combination of endocrine and nonendocrine autoimmune diseases. In type I, which usually begins at age 10 to 12 years, symptoms include candidiasis, hypoparathyroidism, and primary adrenal insufficiency. Pernicious anemia, vitiligo, gonadal failure, alopecia, and chronic hepatitis may also occur. Type II is better known as schmidt's syndrome.
References in periodicals archive ?
Visceral and skin granuloma annulare, diabetes, and polyendocrine disease.
AIRE variations in Addison's disease and autoimmune polyendocrine syndromes (APS): partial gene deletions contribute to APS I.
In patients with both TSH and ACTH deficiency or patients with autoimmune polyendocrine syndrome type II (primary hypothyroidism and Addison's disease), treatment with levothyroxine may precipitate an acute adrenal crisis because thyroxine increases cortisol metabolism [29, 30].
Last but not least, autoimmune polyendocrine syndrome type 1 (APS-1) should be mentioned.
Sagasta et al., "Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus, and polyendocrine autoimmunity," Neurology, vol.
Gottlieb, "Autoimmune polyendocrine syndromes," The New England Journal of Medicine, vol.
Gustafsson et al., "Cytochrome P450IA2 and aromatic L-amino acid decarboxylase are hepatic autoantigens in autoimmune polyendocrine syndrome type I," FEBS Letters, vol.
Hashimoto's thyroiditis concomitant with sequential autoimmune hepatitis, chorea and polyserositis: a new entity of autoimmune polyendocrine syndrome?
Inactivating mutations in the AIRE gene cause the rare autosomal recessive disease autoimmune polyendocrine syndrome type 1, a condition with a similar autoimmune profile to Down syndrome.