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Related to polycistronic: Polycistronic mRNA


Pertaining to mRNA carrying information for the synthesis of more than one protein.


a single mRNA encoding several different polypeptide chains.

polycistronic mRNAs
a mRNA found in prokaryotes that encodes more than one protein. See also monocistronic mrnas.
References in periodicals archive ?
Confirmation of cloning: The presence of polycistronic cassette in cultured colonies was confirmed by following methods.
Polycistronic operon: Figure 1 shows the result of polycistronic construct to co-express the heavy and light chains antibody F(ab')2 fragment under the control of one promoter.
The F(ab')2 fragment is shown in polycistronic construct.
Using the tandem genes, Carey created iPS cells containing just a single copy of the polycistronic vector instead of multiple integrations of the viruses.
MicroRNA 17-92, polycistronic miRNA, is amplified and upregulated in a variety of B-cell lymphomas and is transcriptionally regulated by C-MYC.
The function of the viral E6 protein complements that of E7 and, in the high-risk HPV types, the two proteins are expressed together from a single polycistronic mRNA species (16).
Numerous approaches have been directed against the polycistronic E6/E7 mRNA to block the expression of both E6 and E7 in HPV-positive cervical cancer cells.
To facilitate co-delivery of an extended spectrum of antigenic and immune-stimulating information, complex expression systems using polycistronic cassettes, bidirectional promoters, fusion constructs, or multiple, independent transcription units on a single plasmid have been incorporated into DNA vaccines (31).
Because of the genomic organization of SARS CoV, all polycistronic viral mRNA molecules contain the SARS N gene (11,12).
Because the processing of polycistronic RNA transcripts depends on the secondary structure and precise cleavage of the precursor, nucleotides between two tRNA genes may be important for structural recognition by the processing enzyme.