1989, "Heat Capacities and Volumes of Some Polybasic
Carboxylic Acids in Water at 298.
Compound 48/80 and other polybasic
compounds are shown to activate G proteins (20,21).
pH calculations involving hydrolysis, polybasic
acids, buffer solutions and the common titrametric methods are treated in chapters 7 through 12 with most of the templates providing for graphing.
The HA cleavage site showed polybasic
properties RNSPLRERRRKR*GLFGAIA, confirming the high pathogenicity of the virus.
Highly Pathogenic Influenza strains of all clades possess the polybasic
This process showed the polybasic
cleavage site PLRERRRKR/ GLF from multiple bird swab and tissue samples from each shed.
It is comprised of applying an organic acid to a substrate to form a layer and drying the layer, wherein the organic acid has at least two acid groups and is selected from the group consisting of a graft polymer, a polybasic
carboxylic acid, a polymer of an unsaturated carboxylic acid and a co-polymer of an unsaturated carboxylic acid.
The amino acid sequence of the HA1/HA2-connecting peptide of HA is a major determinant of pathogenicity in terrestrial poultry, and the pathogenicity of highly pathogenic subtype H5N1 and H7N3 viruses is influenced by the presence of a polybasic
cleavage site in the connecting peptide (32).
The virus's hemagglutinin (HA) cleavage site had the polybasic
amino acid sequence PQRERRRKRGLF, which is characteristic of HPAIVs (22).
9 * PB, polybasic
protein; 008, A/duck/eastern China/008/2008(H5N5); 108, A/duck/eastern China/108/2008(H5N1); 031, A/duck/eastern China/031/2009(H5N5); 909, A/duck/eastern China/909/2009(H5N1); 013, A/duck/Yangzhou/013/2008(H6N5); PA, polymerase acidic protein; HA, hemagglutinin; NP, nucelocapsid protein; NA, neuraminidase; M, matrix protein; NS, nonstructural protein.