poliovirus vaccine


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poliovirus vaccine

a vaccine prepared from poliovirus to confer immunity to it. The inactivated poliovirus vaccine (IPV) is a suspension of three strains of polioviruses that have been inactivated in formalin so that normal activity of the organisms has been destroyed. IPV is given subcutaneously at 2 mo, 4 mo, between 6 and 18 mo, and between 4 and 6 yr, and is the form of vaccination recommended in the United States. A trivalent live oral form of vaccine, TOPV, rarely causes vaccine-associated paralysis after administration. This reaction has not occurred with IPV and is the reason that use of TOPV is being discontinued in the United States. TOPV is, nevertheless, the treatment of choice in areas of the world where polio is still endemic. Also called poliomyelitis vaccine; poliovirus vaccine, inactivated; Salk vaccine.

poliovirus vaccine, inactivated

po·li·o·vi·rus vac·cine

(pō'lē-ō-vī'rŭs vak-sēn')
1. Inactivated poliovirus vaccine (IPV), an aqueous suspension of inactivated strains of poliomyelitis virus (types 1, 2, and 3) used by injection.
2. Oral poliovirus vaccine (OPV), an aqueous suspension of live, attenuated strains of poliomyelitis virus (types 1, 2, and 3) given orally for active immunization against poliomyelitis.
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Genetic basis of attenuation of the Sabin oral poliovirus vaccines.
Vaccine-derived polioviruses and children with primary immunodeficiency, Iran, 1995-2014
To minimize the risks for paralytic poliomyelitis associated with PV2, vaccination with the inactivated poliovirus vaccine (IPV) will be needed for the foreseeable future (6).
Progress Toward Containment of Poliovirus Type 2--Worldwide, 2017
TAK-361S is a combination of the combined diphtheria, tetanus, and acellular pertussis vaccine (trivalent vaccine) that has already been marketed by the company, and the inactivated poliovirus vaccine derived from Sabin strain (Sabin-IPV).
Takeda advances quadrivalent vaccine TAK-361S into Phase II development
The normal four-dose schedule for inactivated poliovirus vaccine (IPV) sets doses at ages 2 months, 4 months, 6-18 months, and 4-6 years (MMWR 2009;58:829-30).
Polio vaccine guidelines updated
health officials: While the injectable, inactivated poliovirus vaccine (the newest, enhanced version is known as E-IPV) carries with it no risk to individuals, it also fails to "donate" protection to other members of society.
Polio policy: a bitter pill to swallow
All countries with PV2 detected in 2017 (except Afghanistan) conducted immunization campaigns using monovalent oral poliovirus vaccine type 2 (mOPV2) in response to cVDPV2 isolates detected in Pakistan and Nigeria.
Virologic monitoring of poliovirus type 2 after oral poliovirus vaccine type 2 withdrawal in April 2016--worldwide, 2016-2017
With this funding, Takeda will develop, license and supply at least 50 million doses per year of Sabin-strain inactivated poliovirus vaccine (sIPV) to more than 70 developing countries.
Japan : Takeda Receives $38 Million Grant from the Bill & Melinda Gates Foundation to Support Polio Eradication in Developing Countries
The patient, a 10-month-old boy, was born at term on October 28, 2010; X-linked immunodeficiency syndrome was diagnosed after he received 3 scheduled doses of polio vaccine (1 OPV dose at birth and 2 inactivated poliovirus vaccine doses at 10 and 14 weeks).
Immunodeficiency-associated vaccine-derived poliovirus type 3 in infant, South Africa, 2011
The American Academy of Pediatrics (AAP) recommends a four-dose, standard schedule for administration of inactivated poliovirus vaccine (IPV) to U.
AAP provides updated policy on polio protection: the policy is important 'to alert families to the risk of exposure to polio related to international travel.'
The insert now includes the statement that lnfanrix (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed) "may be used to complete a DTaP vaccination series initiated" with Pediarix (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B [Recombinant] and Inactivated Poliovirus Vaccine Combined), because both vaccines use the same pertussis antigen components, according to a statement issued by the FDA.
Infanrix insert updated with more safety data

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