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physician office laboratory

A diagnostic lab in a physician’s office with an abbreviated menu of tests that can be performed while the patient is in the office, so the physician can better manage the patient.

HIV-1 gene

Any of the genes present in the human immunodeficiency virus. See AIDS.
HIV genes
art/trs gene rev gene, see there.
env gene Encodes viral coat proteins gp 120 and gp 41, which mediate CD4 binding and membrane fusion, controlled by tat and rev
gag gene Encodes nucleocapsid core proteins including p24
nef gene 3´ orf, B gene, ORF-2 gene Encodes a protein of unknown function found in infected Pts that may down-regulate viral expression–nef deletion results in a five-fold increase in viral DNA synthesis and replication
pol gene Encodes reverse transcriptase, protease, integrase and ribonuclease
R gene Encodes TAR–transcription activating response element, which has a nonspecific immunodeficiency effect
rev gene art/trs gene Encodes a 19 kD post-transcriptional protein regulator required for HIV replication, up-regulating HIV synthesis by transactivating anti-repression, ↑ levels of envelope RNA by regulating the env gene; inactivation of rev prevents viral replication–as measured by the successful production of the p24 glycoprotein by infected monocytes can be massively ↑ by adding cytokines to culture medium
tat gene Encodes a potent 14 kD transcription activator that amplifies HIV replication, the inactivation prevents viral replication
vif gene Facilitates infectivity of free HIV
vpr gene Encodes a weak transcription activator
vpu gene Unique to HIV-1, encodes a 16 kD product which, when mutated, has a 5-10-fold Ø in replicative capacity and is critical for efficient budding of virions NEJM 1991; 324:308rv
†Gene encoding regulatory protein
‡Gene encoding structural protein


Abbreviation for physician office laboratory.


A viral gene which, in retroviruses, acts in conjunction with the gag gene to direct the formation of gag-pol messenger RNAs.
References in periodicals archive ?
Guerrillas carried Pol Pot's corpse to its makeshift pyre opposite the wooden shack where it had been displayed to the world.
King Norodom Sihanouk, who returned to Cambodia on Saturday, also said Pol Pot should face an international tribunal.
On his long journey to gain political power in Cambodia, Pol Pot could rely on foreign assistance.
There is definitely another POL accreditation agency on the block, and it plans to do business with you.
During his lessons, Pol Pot strides up and down the aisles crowded with students, peppering them with questions in the same Socratic style as a Harvard law professor.
Khut Khon, Pol Pot's former aide at Anlong Veng, scoffed at the idea of ''venerating'' a dictator who spent much of his life trying to eradicate religion from Cambodia's collective psyche, but many people still believe in praying to water, forest and land spirits for luck and health -- apparently even to one as evil in life as Pol Pot.
New Acquisition: POL has acquired 11% working interest of GoP in Adhi field through a hidding process.
Thailand denied it had made a deal with the United States to capture Pol Pot, but said the issue may have come up in regular talks between the two countries.
The sentencing of Pol Pot to life imprisonment does provide comfort; we finally know that the man responsible for the death of our loved ones can no longer commit any genocidal acts.
Pol Pot, 69, condemned TWO MILLION people to death in the Asian country's infamous Killing Fields.
The survey respondents reported an overall decrease in POL efficiency; that is, increased test costs were experienced by 69%, 73%, and 78% of POLs with 1 to 4, 5 to 14, and greater than 14 physicians, respectively.
090100247 0843ILT047PNST POLs Now Subject to Federal Standards