pokeweed mitogen


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poke·weed mi·to·gen (PWM),

a mitogen (lectin) from Phytolacca americana (pokeweed) that stimulates chiefly B lymphocytes.

pokeweed mitogen

A carbohydrate-binding lectin isolated from Phytolocca americana that stimulates growth and proliferation of B cells in culture, resulting in production of cytoplasmic or surface immunoglobulins.

pokeweed mitogen

Abbreviation: PWM
A mitogen isolated from the pokeweed plant, Phytolacca americana. In the presence of T lymphocytes, it has the capacity to induce primed B lymphocytes to proliferate and differentiate into plasma cells.
See also: mitogen

pokeweed mitogen

An agent, useful for promoting MITOSIS especially in B lymphocytes, derived from the North American plant, Phytolacca americana .
References in periodicals archive ?
Many lectins and carbohydrates are known to stimulate different cell types, such as PHA and Concanavalin A which stimulate T cells, pokeweed mitogen which stimulates B and T cells and LPS which stimulates B cells and monocytes (Janeway et al.
We tested in vitro stimulation of lymphocytes using pokeweed mitogen (PWM; Gibco, Paisley, Scotland), concanavalin A (Con A; Pharmacia, Uppsala, Sweden), phytohemagglutinin (PHA; Wellcome, Dartford, UK), or OKT3 mAb (anti-CD3; Ortho) in three different concentrations.
4,30] Hypnosis was also used to increase the subject's lymphocyte proliferative response to pokeweed mitogen.