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A neurogenic Drosophila gene of the major intrinsic protein family, which has cell adhesive functions that may be important for Drosophila neurogenesis. It is essential for proper differentiation of ectoderm; it acts synergistically with neurogenic locus proteins Notch and Delta during the separation of neural and epidermal cell lineages in response to the lateral inhibition signal; it has voltage-insensitive monovalent cation channel. Ion transport in big brain is blocked by divalent cations
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