point lesion

point lesion

a disruption of single chemical bonds caused by effects of ionizing radiation on a macromolecule. Also called molecular lesion.
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If the radiation damage is sufficient to change or delete a purine or pyrimidine base, a point lesion may occur.
He notes that 3 major effects cause radiation damage to a macromolecule (such as DNA) in solution in vitro: main-chain scission, cross-linking and point lesions.
5) The severe form of the disease is characterized by a mosaic-like mucosal pattern with red point lesions and/or cherry-red spots or black-brown spots.