Intense pulsed light works well in patients with both pigmentary and vascular changes, especially for poikiloderma
with brown and red pigment.
The differential diagnosis of melasma should be made with post-inflammatory pigmentation, pigmented cosmetic dermatitis, hyperthyroidism, actinic lichen planus, HIV-associated pigmentation, drug-induced facial pigmentation, and poikiloderma
Affected individuals characteristically have facial erythema, poikiloderma
(altered skin pigmentation, atrophy, and telangiectasias), hyperkeratosis, small stature, and skeletal defects .
Dermatomyositis is a rare (incidence, 1.16-19 per million) and freguently heterogeneous disease characterized by proximal greater than distal muscle weakness, violaceous poikiloderma
, typically involving the eyelids and malar area, anterior upper chest and back, extensor surfaces, and sun exposed areas (3).
The patient was emaciation, and physical examination revealed heliotrope sign, poikiloderma
involving the face, “V” sign of the chest, and the upper arm, nail fold telangiectasia, and large well-defined ulcers on the abdomen, back, and upper arms, there was no Gottron sign [Figure 1].
KS is associated with acral skin blistering inducible by trauma, mucosal inflammation, photosensitivity, progressive pigmentation, telangiectasia, and skin atrophy (Poikiloderma
Hennekam, "Prenatal and postnatal growth retardation, microcephaly, developmental delay, and pigmentation abnormalities: naegeli syndrome, dyskeratosis congenita, poikiloderma
Clericuzio type, or separate entity?" European Journal of Medical Genetics, vol.
A This sounds like it may be a condition called "poikiloderma
of Civatte," a term used to describe a change in the color and/or texture of the skin due to sun-related aging.
, and episodic angioedema can also occur.
(10) reported a case of a 38 year old male patient who presented with generalised erythema, scaling and poikiloderma
, with multiple nodulo-ulcerative lesions for 2 years, suggestive of lepromatous leprosy.
It can be associated with poikiloderma
, tardive pancytopenia, multisystemic affection: testicular atrophy, pulmonary fibrosis, liver cirrhosis.
The important essential features of DKC are caused predominantly by missense mutations in the DKC1 gene linked to Xq28,8 although autosomal forms may harbour abnormalities in the RNA component of telomerase.9 Clinically it manifests as atrophy, telangiectasia, and pigmentation of skin (poikiloderma
), nail dystrophy, and oral leukoplakia.7 Bone marrow failure and malignancy7 commonly manifest in the second and third decades.