Another genetic cause of
poikilocytosis is the irreversible sickle cells seen in sickle syndromes (Figure 3--Slide H).
HPP is characterized by erythrocyte
poikilocytosis and fragmentation, erythrocyte budding, spherocytes, triangulocytes, micropoikilocytosis, microspherocytosis, and occasional elliptocytes, which together result in a pattern reminiscent of thermal injury.
Mild hypochomia, anisocytosis and
poikilocytosis were observed on peripheral blood smear.
Her baseline laboratory parameters demonstrated normochromic anaemia with anisocytosis and
poikilocytosis. Her haemoglobin was 11.9gm/dl and she had leukocytosis (TLC count was 44.4 x 109/L) with 95% blast cells on peripheral film.
1) showed a leukoerythroblastic picture with marked polychromasia, large number of circulating nucleated red blood cells and marked
poikilocytosis including blister cells, spherocytes and echinocytes, consistent with oxidative hemolysis.
Initial tests showed a leukocyte count of 13.8 x [10.sup.9]/L (reference 9-30) with atypical lymphocytes; a hemoglobin level of 202 g/L (reference 135-195); abnormal erythrocyte morphology, including macrocytosis, polychromasia, and
poikilocytosis; and a platelet count of 98,000 x [10.sup.9]/L (reference 140-440).
However, 9% of all sheep displayed mild acanthocytosis (+1 to +2) as the only evidence of red blood cell abnormality (
poikilocytosis).
And the severity of
poikilocytosis was attenuated in the presence of chloroquine (Figure 2).
Optical microscopy showed spiculated erythrocytes and
poikilocytosis; major changes in the plasma membrane were detected by electron microscope.
Peripheral blood smear revealed anisocytosis,
poikilocytosis, along with target cells and contracted red blood cells.
The peripheral blood smear was notable for marked microcytosis, hypochromia, polychromasia,
poikilocytosis, and anisocytosis with numerous erythroblasts.
