Another genetic cause of poikilocytosis
is the irreversible sickle cells seen in sickle syndromes (Figure 3--Slide H).
HPP is characterized by erythrocyte poikilocytosis
and fragmentation, erythrocyte budding, spherocytes, triangulocytes, micropoikilocytosis, microspherocytosis, and occasional elliptocytes, which together result in a pattern reminiscent of thermal injury.
Mild hypochomia, anisocytosis and poikilocytosis
were observed on peripheral blood smear.
Her baseline laboratory parameters demonstrated normochromic anaemia with anisocytosis and poikilocytosis
. Her haemoglobin was 11.9gm/dl and she had leukocytosis (TLC count was 44.4 x 109/L) with 95% blast cells on peripheral film.
1) showed a leukoerythroblastic picture with marked polychromasia, large number of circulating nucleated red blood cells and marked poikilocytosis
including blister cells, spherocytes and echinocytes, consistent with oxidative hemolysis.
Initial tests showed a leukocyte count of 13.8 x [10.sup.9]/L (reference 9-30) with atypical lymphocytes; a hemoglobin level of 202 g/L (reference 135-195); abnormal erythrocyte morphology, including macrocytosis, polychromasia, and poikilocytosis
; and a platelet count of 98,000 x [10.sup.9]/L (reference 140-440).
However, 9% of all sheep displayed mild acanthocytosis (+1 to +2) as the only evidence of red blood cell abnormality (poikilocytosis
And the severity of poikilocytosis
was attenuated in the presence of chloroquine (Figure 2).
Optical microscopy showed spiculated erythrocytes and poikilocytosis
; major changes in the plasma membrane were detected by electron microscope.
Peripheral blood smear revealed anisocytosis, poikilocytosis
, along with target cells and contracted red blood cells.
The peripheral blood smear was notable for marked microcytosis, hypochromia, polychromasia, poikilocytosis
, and anisocytosis with numerous erythroblasts.