podosome


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podosome

(pod′ŏ-sōm″) [ podo- + -some]
A cellular structure composed of actin and integrins, used by mesenchymal cells to hold them to each other or to neighboring cells. Podosomes are found, e.g., on osteoclasts attached to bone matrix.
References in periodicals archive ?
Courtneidge, "MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro," The Journal of Cell Biology, vol.
Takenawa, "Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts," Cancer Research, vol.
Chan et al., "TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent," The Journal of Cell Biology, vol.
The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells.
They found that the nicotine exposure caused the formation of podosome rosettes, further causing holes in the cells.
Hai's experiments, nicotine appeared to drive the formation of a kind of cellular drill called podosome rosettes, which are members of the invadosome family, consisting of invadopodia, podosomes and podosome rosettes.
Confocal images showed that, as expected, Myo6 appeared to be associated with F-actin, with similar distributions mainly found around the cell periphery in both types of macrophages (Figures 6(a)(ii) and 6(b)), including possible podosome attachment sites in THP-1 cells (Figure 6(a)(i)).
Resultant levels of elevated [Ca.sup.2+.sub.o] leads to cytoskeletal changes such as podosome assembly (72) that may be linked to PLC activation and the associated rise in ([Ca.sup.2+.sub.i] concentration (76).
Previous reports have identified STIM1 localization in podosome [34], phagosome [34], and cell-matrix adhesion at the front of migrating cells [9].
Pass et al., "The adaptor protein Tks5/fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells," Cancer Cell, vol.
Guillemot et al., "Extracellular matrix rigidity controls podosome induction in microvascular endothelial cells," Biology of the Cell, vol.
Hruska, "Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength," The Journal of Cell Biology, vol.