podophyllotoxins

A range of powerful substances derived from the mandrake root (Podophyllum peltatum ). Podophyllotoxins act as TOPOISOMERASE inhibitors causing breaks in DNA strands. Ironically in view of John Donne's famous reference to mandrake, podophillotoxins are also used locally to treat genital WARTS in both sexes. Brand names of preparations for the latter purpose are Condyline and Warticon.

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Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins.

Synthesis of nitrogen derivatives from podophyllotoxin.

Sintesis de derivados nitrogenados de la podofilotoxina

The podophyllotoxins (etoposide and tenisopide) are derived from the May apple plant (Podophyllum peltatum).

Podophyllotoxins and camptothecan analogs are also effective as Topoisomerase inhibitors.

Conventional treatments: chemotherapy--a medical 'solution'

Canel says the mayapple adds a glucose molecule to podophyllotoxins so the compound can be safely stored until the plant is attacked.

This allowed the release of large amounts of stored podophyllotoxins," says Canel.

Mayapple's Cancer-Fighting Precursor

While, etoposide (Eto) is a semi synthetic derivative of the podophyllotoxins, which inhibits DNA synthesis by inhibiting DNA topoisomerase II which is cell cycle dependent and phase specific, affecting mainly the S and G2 phases (19).

Combined treatment of androgen-independent prostate cancer cell line du145 with chemotherapeutic agents and lithium chloride: effect on growth arrest and/or apoptosis

They are semisynthetic derivatives of podophyllotoxin, a lignan derived from American mandrake (Podophyllum peltatum L).

Cytotoxicity of the bisphenolic honokiol from Magnolia officinalis against multiple drug-resistant tumor cells as determined by pharmacogenomics and molecular docking

To begin with, the compounds from higher plants include Berbamine, Butulinic acid, Camptothecin, Cucurbitacin, Ellipticine, Flavopiridol, Homoharringtonine, Silvestrol, Berberine, Daphnoretin and Podophyllotoxin.

An in silico based comparison of drug interactions in wild and mutant human [beta]-tubulin through doclqing studies

These are semi-synthetic derivatives of podophyllotoxin, which is an extract from the mandrake plant.

Chemotherapy in eye cancer: chemotherapy is one of several treatment strategies used to halt the uncontrolled division, proliferation and unpredictable growth patterns of malignant cells

Beside well-established anticancer drugs such as etoposide and temposide, highly cytotoxic phytochemicals such as podophyllotoxin were included in this panel of compounds.

The lignan, (-)-sesamin reveals cytotoxicity toward cancer cells: pharmacogenomic determination of genes associated with sensitivity or resistance

These methods have yielded important discoveries including vincristine, vinblastine, the podophyllotoxin derivatives, lO-hydroxy-camptothecin and Taxol (Suffness and Douors, 1979; Wani et al.