podophyllotoxins

A range of powerful substances derived from the mandrake root (Podophyllum peltatum ). Podophyllotoxins act as TOPOISOMERASE inhibitors causing breaks in DNA strands. Ironically in view of John Donne's famous reference to mandrake, podophillotoxins are also used locally to treat genital WARTS in both sexes. Brand names of preparations for the latter purpose are Condyline and Warticon.

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Cytotoxicity, post-treatment recovery, and selectivity analysis of naturally occurring podophyllotoxins from Bursera fagaroides var.

The Antiproliferative Activity of Colchicum umbrosum Plant Extract and Paclitaxel on C-41 and Vero Cells

Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications," Journal of Natural Products, vol.

MCM-41-Accelerated PWA Catalysis of Friedel-Crafts Reaction of Indoles and Isatins

A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007.) Curr Med Chem 2009;16(3): 327-349.)

Podophyllotoxins: current status and recent developments.

An in silico based comparison of drug interactions in wild and mutant human [beta]-tubulin through doclqing studies

* The podophyllotoxins (etoposide and tenisopide) are derived from the May apple plant (Podophyllum peltatum).

Conventional treatments: chemotherapy--a medical 'solution'

The ARS-Mississippi team has found an efficient way to extract podophyllotoxins, which the mayapple stores in the form of glucosides.

Mayapple's Cancer-Fighting Precursor

While, etoposide (Eto) is a semi synthetic derivative of the podophyllotoxins, which inhibits DNA synthesis by inhibiting DNA topoisomerase II which is cell cycle dependent and phase specific, affecting mainly the S and G2 phases (19).

Combined treatment of androgen-independent prostate cancer cell line du145 with chemotherapeutic agents and lithium chloride: effect on growth arrest and/or apoptosis

Damayanthi Y, Lown JW (1998) Podophyllotoxins: current status and recent developments.

Potato disc tumor induction assay: a multiple mode of drug action assay

They are semisynthetic derivatives of podophyllotoxin, a lignan derived from American mandrake (Podophyllum peltatum L).

Cytotoxicity of the bisphenolic honokiol from Magnolia officinalis against multiple drug-resistant tumor cells as determined by pharmacogenomics and molecular docking

These are semi-synthetic derivatives of podophyllotoxin, which is an extract from the mandrake plant.

Chemotherapy in eye cancer: chemotherapy is one of several treatment strategies used to halt the uncontrolled division, proliferation and unpredictable growth patterns of malignant cells

Beside well-established anticancer drugs such as etoposide and temposide, highly cytotoxic phytochemicals such as podophyllotoxin were included in this panel of compounds.

The lignan, (-)-sesamin reveals cytotoxicity toward cancer cells: pharmacogenomic determination of genes associated with sensitivity or resistance

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