Cytotoxicity, post-treatment recovery, and selectivity analysis of naturally occurring podophyllotoxins
from Bursera fagaroides var.
Isolation of Bridelia ferruginea Anticancer Podophyllotoxins
and Synthesis of 4-Aza-podophyllotoxin Structural Modifications," Journal of Natural Products, vol.
A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007.) Curr Med Chem 2009;16(3): 327-349.)
Podophyllotoxins: current status and recent developments.
* The podophyllotoxins
(etoposide and tenisopide) are derived from the May apple plant (Podophyllum peltatum).
The ARS-Mississippi team has found an efficient way to extract podophyllotoxins
, which the mayapple stores in the form of glucosides.
While, etoposide (Eto) is a semi synthetic derivative of the podophyllotoxins
, which inhibits DNA synthesis by inhibiting DNA topoisomerase II which is cell cycle dependent and phase specific, affecting mainly the S and G2 phases (19).
Damayanthi Y, Lown JW (1998) Podophyllotoxins
: current status and recent developments.
They are semisynthetic derivatives of podophyllotoxin
, a lignan derived from American mandrake (Podophyllum peltatum L).
These are semi-synthetic derivatives of podophyllotoxin
, which is an extract from the mandrake plant.
Beside well-established anticancer drugs such as etoposide and temposide, highly cytotoxic phytochemicals such as podophyllotoxin
were included in this panel of compounds.