podophyllotoxins

podophyllotoxins

A range of powerful substances derived from the mandrake root (Podophyllum peltatum ). Podophyllotoxins act as TOPOISOMERASE inhibitors causing breaks in DNA strands. Ironically in view of John Donne's famous reference to mandrake, podophillotoxins are also used locally to treat genital WARTS in both sexes. Brand names of preparations for the latter purpose are Condyline and Warticon.
References in periodicals archive ?
Cytotoxicity, post-treatment recovery, and selectivity analysis of naturally occurring podophyllotoxins from Bursera fagaroides var.
Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications," Journal of Natural Products, vol.
A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007.) Curr Med Chem 2009;16(3): 327-349.)
Podophyllotoxins: current status and recent developments.
* The podophyllotoxins (etoposide and tenisopide) are derived from the May apple plant (Podophyllum peltatum).
The ARS-Mississippi team has found an efficient way to extract podophyllotoxins, which the mayapple stores in the form of glucosides.
While, etoposide (Eto) is a semi synthetic derivative of the podophyllotoxins, which inhibits DNA synthesis by inhibiting DNA topoisomerase II which is cell cycle dependent and phase specific, affecting mainly the S and G2 phases (19).
Damayanthi Y, Lown JW (1998) Podophyllotoxins: current status and recent developments.
They are semisynthetic derivatives of podophyllotoxin, a lignan derived from American mandrake (Podophyllum peltatum L).
Beside well-established anticancer drugs such as etoposide and temposide, highly cytotoxic phytochemicals such as podophyllotoxin were included in this panel of compounds.