podophyllotoxin


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Related to podophyllotoxin: etoposide, podophyllin, Imiquimod, Podofilox

podophyllotoxin

 [pod″o-fil″o-tok´sin]
a highly toxic compound that is the main active component of podophyllum resin and has cathartic and caustic properties. Some of its less toxic derivatives, such as etoposide and teniposide, are used as antineoplastic agents.

pod·o·phyl·lo·tox·in

(pod'ō-fil'ō-tok'sin),
A toxic polycyclic substance with cathartic properties present in podophyllum; has antineoplastic action.

podophyllotoxin

(pŏd′ə-fĭl′ə-tŏk′sĭn)
n.
A toxic polycyclic substance having cathartic properties and antineoplastic activity.
References in periodicals archive ?
sabina fruit on male rats in vivo and investigated the possible mechanisms of action of podophyllotoxin on rat epididymal epithelial cells in vitro, and hence they might be developed as potential nonhormonal male contraceptives.
Research practices in herbal medicinal plant: a case study of podophyllotoxin. Annals of Library and Information studies.
Medicinal plant name Isolated compounds (structures are shown in Figure 1) Taxus baccata Cabazitaxel Colchium autumnale Colchicine (autumn crocus) Combretum caffrum Combretastatin Taxus species Docetaxol Glycyrrhiza uralensis Isoliquiritigenin Needles of yew trees Larotaxel Taxus baccata Podophyllum peltatum Podophyllotoxin Podophyllum emodi Taxus brevifolia Paclitaxel Polygonum roots, Peanut Resveratrol seeds, Berries and grapes Broussonetia papyrifera 2S-abyssinone II Verubulin Catharanthus roseus Vinblastine G.
Podophyllotoxin is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species which is again an antitumor agent (57-59).
During October 2005-December 2009, the patient received topical and ablative treatments for the warts (salicylic acid, podophyllotoxin, 5-fluoruracil cream, imiquimod 5% cream, cryosurgery, surgical curettage, electrocautery, and CO2 laser therapy), but clinical improvement was not sustained.
Palazon, "Salicylic acid improves podophyllotoxin production in cell cultures of Linum album by increasing the expression of genes related with its biosynthesis," Biotechnology Letters, vol.
Effect of major nutrients on podophyllotoxin production in Podophyllum hexandrum suspension cultures.
Effects on bone marrow cells of oral treatment with podophyllotoxin derivatives in rheumatoid arthritis.
Topical treatments include 10-20% potassium hydroxide, cryotherapy (applying liquid nitrogen for 6-9 seconds), trichloroacetic acid (35-100%), topical tretinoin and imiquimod, podophyllotoxin (20-25%), potassium hydrochloric solution (10-30% solution) or silver nitrate (40%).
Some of the useful plant drugs include vinblastine, vincristine, Taxol, Podophyllotoxin, camptothecin, digitoxigenin, gitoxigenin, digoxigenin, tubocurarine, morphine, codeine, aspirin, atropine, Pilocarpine, capsicum, Ellison, curcumin, artemesinin and ephedrine among others.
Jackson and Dewick (1984), for example, found that the content of podophyllotoxin, which is isolated from podophyllin (a resin produced by species of the genus Podophyllum, commonly known as 'may-apple'), is much higher (4.3% of dry weight) in the Himalayan species Podophyllum hexandrum than in the American species P peltatum (0.25%).