podophyllotoxin


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Related to podophyllotoxin: etoposide, podophyllin, Imiquimod, Podofilox

podophyllotoxin

 [pod″o-fil″o-tok´sin]
a highly toxic compound that is the main active component of podophyllum resin and has cathartic and caustic properties. Some of its less toxic derivatives, such as etoposide and teniposide, are used as antineoplastic agents.

pod·o·phyl·lo·tox·in

(pod'ō-fil'ō-tok'sin),
A toxic polycyclic substance with cathartic properties present in podophyllum; has antineoplastic action.

podophyllotoxin

(pŏd′ə-fĭl′ə-tŏk′sĭn)
n.
A toxic polycyclic substance having cathartic properties and antineoplastic activity.

podophyllotoxin

[pō′dōfil′ətok′sin]
Etymology: Gk, pous + phyllon, leaf, toxikon, poison
any one of a group of substances derived from the roots of Podophyllum peltatum, a common plant species known as mayapple or American mandrake. Podofilox, a derivative, is prescribed in the topical treatment of condyloma acuminatum and other types of warts. Several podophyllotoxin derivatives have been used as purgatives and studied for their antineoplastic effects, including the inhibition of mitosis. Podophyllotoxins are not recommended for use in early pregnancy.

podophyllotoxin

podophyllin resin.
References in periodicals archive ?
Currently, add the researchers, podophyllotoxin is produced commercially using the roots and rhizomes of Indian mayapple, the endangered species harvested from the wild in India, Pakistan, Nepal, and China.
emodi is prized for its podophyllotoxin, which is used as the starting material for producing the antitumor agent etoposide," says Agricultural Research Service plant physiologist Camilo Canel.
It can be speculated that compounds revealing comparably high cytotoxicity than podophyllotoxin such as deoxypodophyllotoxin or austrobailignan-1 might also be too toxic for use in cancer therapy.
The pharmacokinetic characteristics of teniposide differ from those of etoposide, another podophyllotoxin.
2007), Podophyllotoxin producing Fusarium oxysporum from Sinopodophyllum (Kour et al.
Several workers have reported the use of endophytes for the production of pacitaxel, camptothecin, podophyllotoxin, hypericin, and gentiopicrin isolated from the hosts Taxus cuspidata, Nothapodytes foe tida/Campto theca acuminata, Podophyllum peltatum, Hypericum perforatum, and Gentiana macrophylia, respectively, although there are no reports of successful industrial scale-ups (Zhao et al.
The search for anti-cancer drugs from plant sources started in the 1950s, with the discovery of the vinca alkaloids (vinblastine and vincristine) and podophyllotoxin.
Activity of a new glycosidic lignan derivative (VP16-213) related to podophyllotoxin in experimental tumors.
hexandrum are reported to contain lignans such as podophyllotoxin, 4-demethylpodophyllotoxin, podophyllotoxone, podophyllotoxin glycoside, 4-demethylpodophyllotoxone, deoxypodophyllotoxin, dehydropodophyllotoxin,and other aryl tetrahydronaphthalene lignans (Singh and Shah, 1994; Wong et al.
The cytotoxic potentials of the extracts on rat skeletal myoblast (L6) cells were also assessed and compared to that of podophyllotoxin.
In order to determine the selectivity, the extracts were also tested on rat skeletal myoblasts (L6 cells) by using podophyllotoxin as positive control (Table 1).