podofilox


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podofilox

 [po-dof´ĭ-loks]
a corrosive preparation of podophyllotoxin that inhibits cell mitosis and is used for topical treatment of venereal warts.

po·do·fil·ox

(pō-dof'il-oks),
An antimitotic agent derived from species of Juniperus and Podophyllum; used to treat external genital and perianal warts.
References in periodicals archive ?
TABLE Self-administered medications for HPV Medication Method Cost Podofilox 0.5% Apply twice daily Gel 0.5%, one 3.5-g solution or gel for 3 days, then tube: $164 Solution 0.5% (podophyllotoxin) off 4 days.
PATIENT-APPLIED THERAPIES Drug Dosage Cost/Container imiquimod apply three times $11.80 * (Aldara) per week podofilox apply twice a day $103.62 * for 3 days, 4 days off, repeat Drug Comment + imiquimod Used as 5% cream.
Patient-applied treatments include imiquimod and podofilox. Agents administered by providers include podophyllin resin, trichioroacetic acid, and bichioroacetic acid.
PATIENTS-APPLIED THERAPIES Drug Dosage Cost/Container imiquimod apply three times $11.80 * (Aldara) per week podofilox apply twice a day $103.62 * for 3 days, 4 days off, repeat Drug Comment + imiquimod Used as 5% cream.
PATIENT-APPLIED THERAPIES Drug Dosage Cost/Container imiquimod apply three $11.80 * (Aldara) times per week podofilox apply twice $103.62 * a day for 3 days, 4 days off, repeat Drug Comment + imiquimod Used as 5% cream.
Podofilox (Condylox), imiquimod (Aldara), cryotherapy, and surgical options all seem reasonable alternatives that are superior to podophyllin.
Nonsurgical treatments that are beneficial in eradicating genital warts are podofilox (Condylox) (8 randomized controlled trials [RCTs] with 1035 participants), imiquimod (Aldara) (2 RCTs with 968 participants), and intralesional interferon (8 RCTs).
Data are lacking on recurrence rates with imiquimod, podofilox, and intralesional interferon.
Pain occurs in less than 20% of people with imiquimod, cryotherapy, podophyllin, and electrosurgery; 39% with topical interferon; 44% with electrosurgery; 75% with podofilox; and 100% with surgical excision or laser surgery.