pneumolysin

(nū-mŏl′ĭ-sĭn)

A hemolytic toxin produced by pneumococci.

References in periodicals archive ?

Multiplex real time polymerase chain reaction was done to detect the genes encoding the pneumococcal pneumolysin using primers shown in Table 2.

Streptococcus pneumoniae serotype prevalence and antibiotic resistance among young children with invasive pneumococcal disease: experience from a tertiary care center in South India

The objective of present study is to gain more knowledge about the function of important domain of the toxin pneumolysin. This study aims to analyze the structural and functional features of pneumolysin and to investigate the residues involved in its pathogenicity.The major virulence factor of this bacterium is a protein, pneumolysin, which is the member of thiol-activated cytolysins.

Structural, Functional and Evolutionary study of In silico Three Dimensional Model of Pneumolysin

The impaired immune response to pneumococcal antigen pneumolysin due to HIV infection facilitates bacterial invasion [70].

Coexpression Analysis of Transcriptome on AIDS and Other Human Disease Pathways by Canonical Correlation Analysis

Clitheroe et al., "Sensitivities of human monocytes and epithelial cells to pneumolysin are different," Infection and Immunity, vol.

Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines

It has also been shown that pneumolysin causes microscopic lesions in the myocardium [55].

Invasive Pneumococcal Disease: Still Lots to Learn and a Need for Standardized Data Collection Instruments

Kim et al., "MKP1 regulates the induction of MCP1 by Streptococcus pneumoniae pneumolysin in human epithelial cells," Molecules and Cells, vol.

Effect of Shin'iseihaito (Xinyiqingfeitang) on Acute Streptococcus pneumoniae Murine Sinusitis via Macrophage Activation

Streptococcus pneumoniae, which secretes pneumolysin that help them to act on the respiratory system of various age groups particularly of children that may be lethal to cause death [9].

Epidemiological Studies of Potent Environmental Pathogen: Streptococcus pneumoniae

Primers ply-894 and ply-974 were described by Corless et al., (11) targeting a specific region of the pneumococcus pneumolysin gene (ply) amplifying a 80 bp amplicon.

Comparison of PCR-based methods for the simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in clinical samples

The pathogenesis of increased susceptibility to pneumococcal infection following RSV infection in mice-model studies has been attributed to RSV G glycoprotein-binding penicillin-binding protein 1a increasing pneumococcal virulence owing to up-regulation of virulence genes, pneumococcal toxin and pneumolysin. This could lead to an increase in the inflammatory response and bacterial adherence to human ciliated epithelial cultures.

Acute viral bronchiolitis in South Africa: viral aetiology and clinical epidemiology

[3,16] was used to modify the toxin of SP, pneumolysin (PLY).

Tailoring the immune response via customization of pathogen gene expression

Effects of cigarette smoke condensate on pneumococcal biofilm formation and pneumolysin. Eur Respir J 41(2):392-395 (2013); http://dx.doi.org/10.1183/09031936.00213211.