This study aims to analyze the structural and functional features of pneumolysin
and to investigate the residues involved in its pathogenicity.
Streptococcus pneumoniae, which secretes pneumolysin
that help them to act on the respiratory system of various age groups particularly of children that may be lethal to cause death .
11) targeting a specific region of the pneumococcus pneumolysin
gene (ply) amplifying a 80 bp amplicon.
The pathogenesis of increased susceptibility to pneumococcal infection following RSV infection in mice-model studies has been attributed to RSV G glycoprotein-binding penicillin-binding protein 1a increasing pneumococcal virulence owing to up-regulation of virulence genes, pneumococcal toxin and pneumolysin
is made up of individual components that assemble into a doughnut-shaped superstructure that punches a hole in the human cell wall, causing the cell to disintegrate.
Neutrophil IL-1[sz] processing induced by pneumolysin
is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux.
Effects of cigarette smoke condensate on pneumococcal biofilm formation and pneumolysin
polymerase chain reaction for diagnosis of pneumococcal pneumonia and empyema in children.
A variety of stimuli can activate NF-[kappa]B by separating I-[kappa]B from them, including cytokines, activators of PKC, Viruses, Oxidant and bacterial components, such as LPS, HSL, peptidoglycan, pneumolysin
, flagellin, slime glycoprotein, bacterial DNA (2-4).
To create their vaccine, the researchers focused on the serotype 3 gene that codes for pneumolysin
, a toxin produced by all pneumococcal strains.
The research, published in the international peer-reviewed journal PLoS Pathogens, found that pneumolysin
, the toxin in the bacteria, also triggers an immune response.
gene encodes the hemolysin species-specific protein toxin produced intracellularly by all clinically relevant pneumococcal serotypes (21).