pneumolysin

[no̅o̅mol′isin]

virulence factor produced by Streptococcus pneumoniae associated with cytolysis.

pneumolysin

(nū-mŏl′ĭ-sĭn)

A hemolytic toxin produced by pneumococci.

References in periodicals archive ?

This study aims to analyze the structural and functional features of pneumolysin and to investigate the residues involved in its pathogenicity.

Structural, Functional and Evolutionary study of In silico Three Dimensional Model of Pneumolysin

Streptococcus pneumoniae, which secretes pneumolysin that help them to act on the respiratory system of various age groups particularly of children that may be lethal to cause death [9].

Epidemiological Studies of Potent Environmental Pathogen: Streptococcus pneumoniae

11) targeting a specific region of the pneumococcus pneumolysin gene (ply) amplifying a 80 bp amplicon.

Comparison of PCR-based methods for the simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in clinical samples

The pathogenesis of increased susceptibility to pneumococcal infection following RSV infection in mice-model studies has been attributed to RSV G glycoprotein-binding penicillin-binding protein 1a increasing pneumococcal virulence owing to up-regulation of virulence genes, pneumococcal toxin and pneumolysin.

Acute viral bronchiolitis in South Africa: viral aetiology and clinical epidemiology

Pneumolysin is made up of individual components that assemble into a doughnut-shaped superstructure that punches a hole in the human cell wall, causing the cell to disintegrate.

Australia : A step closer to Streptocococcus pneumoniae vaccine

Neutrophil IL-1[sz] processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux.

Inhibition of Alveolar Macrophage Pyroptosis Reduces Lipopolysaccharide-induced Acute Lung Injury in Mice

Effects of cigarette smoke condensate on pneumococcal biofilm formation and pneumolysin.

Cigarette smoke may increase microbial virulence

Pneumolysin polymerase chain reaction for diagnosis of pneumococcal pneumonia and empyema in children.

Bacterial causes of empyema in children, Australia, 2007-2009

A variety of stimuli can activate NF-[kappa]B by separating I-[kappa]B from them, including cytokines, activators of PKC, Viruses, Oxidant and bacterial components, such as LPS, HSL, peptidoglycan, pneumolysin, flagellin, slime glycoprotein, bacterial DNA (2-4).

Activation of NF-[kappa] B signalling pathway by inflammatory regulators and associated drug discovering

To create their vaccine, the researchers focused on the serotype 3 gene that codes for pneumolysin, a toxin produced by all pneumococcal strains.

Vaccine made with synthetic gene shows promise against pneumonia

The research, published in the international peer-reviewed journal PLoS Pathogens, found that pneumolysin, the toxin in the bacteria, also triggers an immune response.

A SCIENTIFIC b re a [...]

pneumoniae pneumolysin gene encodes the hemolysin species-specific protein toxin produced intracellularly by all clinically relevant pneumococcal serotypes (21).