A severe inflammatory reaction that ultimately results in both endothelial and pneumocyte
damage leads to the observed severe hypoxaemia.
Evidence of type II pneumocyte
apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia (UIP).
Lamellar bodies are secreted by the type II pneumocyte
and unfold to form tubular myelin and other large aggregates that are absorbed onto the hydrated inner layer of the alveoli.
Multifocal micronodular pneumocyte
hyperplasia is rarely encountered.
Endogenous surfactants, those which occur naturally in the lungs of the baby, are a product of the alveolar type II cell, the granular pneumocyte
, and that natural surfactant consists of 85 to 90 percent lipids and 10 percent proteins, jointly comprising surfactant as we know it, dipalmitoylphosphatidylcholine (DPPC), or lecithin.
Fas/Fas ligand pathway is involved in the resolution of type II pneumocyte
hyperplasia after acute lung injury: evidence from a rat model.
(52) In some instances, tumors that metastasize or grow in the interstitium, including squamous cell carcinoma, can induce a pneumocyte
reaction that can be sufficiently atypical as to raise a concern for lepidic pattern adenocarcinoma (Figure 4, C).
Histologic analysis showed that lesions were similar to those observed in humans and indicated necrotizing bronchointerstitial pneumonia with type II pneumocyte
hyperplasia, abundant fibrin, and streaming mucus in airways.
Moreover, mild acute and/or chronic inflammation, type 2 pneumocyte
hyperplasia, and alveolar extension are also seen in the slide.
At the periphery of the mycotic lesions were foci of type II pneumocyte
hyperplasia, septal fibroplasia, and mononuclear infiltration.
Secretion of mucus proteinase inhibitor and elafin by Clara cell and type II pneumocyte
They also suggested KL-6 was a sensitive indicator of type II pneumocyte
damage, increased permeability of the air-blood barrier, and destruction of the healthy lung parenchyma.