They also suggested KL-6 was a sensitive indicator of type II pneumocyte
damage, increased permeability of the air-blood barrier, and destruction of the healthy lung parenchyma.
Areas of type II pneumocyte
proliferation were observed.
The pathologic findings revealed that the lesions were multifocal and pneumocyte
hyperplasia with atypical epithelial cells [Figure 1]c.
Respiration epithelial cells of posterior intestine are a kind of modified squamous epithelial cells which show the ultrastructural characteristics of both types I and II pneumocyte
of lung alveoli in mammals.
Specific histopathologic features like epidermal hyperplasia with ballooning degeneration and the presence of intracytoplasmic eosinophilic inclusion bodies associated with hyperplasia of pneumocyte
type II were seen in the affected animals.
Recently, we reported that SPP1 promotes pneumocyte
growth and that [Spp1.
biomarkers KL-6 and surfactant protein D reflect the distinct findings of high-resolution computed tomography in nonspecific interstitial pneumonia.
Cuboidal surface cells are morphologically resembling type II pneumocyte
Mutational and radiographic analysis of pulmonary disease consistent with lymphangioleiomyomatosis and micronodular pneumocyte
hyperplasia in women with tuberous sclerosis.
It is known that pneumocyte
type II (P2) is the main source of phospholipid and protein components of pulmonary surfactant (Enhorning, 2008).
9) Pneumocystis is primarily an alveolar pathogen that does not invade the pneumocyte
to which it tightly adheres.
31) Vitamin A deficiency produces profound morphologic alterations in liver and lung parenchyma and impairs pneumocyte