Signs of CCP include rectal bleeding, mucorrhea, diarrhea, and colonic obstruction, similar to other associated disorders.[sup] CCP is associated with a variety of ulcerating diseases including inflammatory bowel disease (ulcerative colitis [UC] and Crohn's disease), infectious colitis, rectal prolapse, solitary rectal ulcer, and diverticulitis, among others.[sup],, CCP can resemble adenoma, adenocarcinoma, lipoma, endometriosis, neurofibroma, pseudopolyps, and pneumatosis coli
.[sup] However, the etiology of CCP is not yet well-defined.
Pneumatosis cystoides intestinalis (PCI), also termed pneumatosis intestinalis, pneumatosis coli (when occurring in colon only), and several other uncommon names in the literature, is a rare condition characterized by multiple gas-filled cystic spaces within the bowel wall.
The present study started with the first author's incidental finding (in case 1) that a condensed podoplanin-immunopositive linear structure was seen around the cystic spaces of pneumatosis coli and superficially resembled the adjacent lymphatic spaces.