Chronic myeloid leukemia is a pluripotential stem cell
disorder characterised by anemia, markedly elevated leucocyte count with shift to left in the myeloid series, basophilia, often thrombocytosis and splenomegaly.
16) Jain proposed metastasis from an undetected primary pancreas tumor and development of a tumor in an aberrant location from the local pluripotential stem cell with the potential for "divergent differentiation as the two alternative theories.
The local pluripotential stem cell transformation theory, even though it is hard to prove, is certainly a strong alternative to the heterotopic pancreas malignant transformation theory and may well be the cause for the presentation in our case as well.
5,6) This divergent differentiation is thought to be related to the pluripotential stem cell
precursors, which have the ability to differentiate into all of these different components.
The primary defect involves a pluripotential stem cell
capable of differentiating into RBCs, granulocytes, and platelets.
Fletcher, Deliberating Incrementally on Human Pluripotential Stem Cell Research, in 2 NBAC, ETHICAL ISSUES IN HUMAN STEM CELL RESEARCH: COMMISSIONED PAPERS E-1, E-16 (2000) [hereinafter COMMISSIONED PAPERS] (alteration in original).
53) Some of these concerns are outlined in Deliberating Incrementally on Human Pluripotential Stem Cell Research and What Has the President Asked of NBAC?
Stem cell researchers have been racing towards this goal since 2006, when techniques for turning ordinary skin cells into induced pluripotential stem cells
(iPSCs) were first reported.
Pluripotential stem cells are present several days after fertilization and can also develop into any cell type but cannot develop into a fetus.
Multipotential stem cells are derived from pluripotential stem cells and can be found in adults.
Pluripotential stem cells
can also differentiate into various kinds of specialized cells when they are appropriately stimulated.