The collaboration with Wernet, Scholer and RheinCell Therapeutics will seek to develop a collection of induced Pluripotential Stem Cell
(iPSC) lines from which differentiated cells and tissues can be generated to provide therapies to repair and regenerate damaged tissues -- with a low chance of immune rejection -- for clinical use by large segments of the patient population.
5,6) This divergent differentiation is thought to be related to the pluripotential stem cell
precursors, which have the ability to differentiate into all of these different components.
The primary defect involves a pluripotential stem cell
capable of differentiating into RBCs, granulocytes, and platelets.
Fletcher, Deliberating Incrementally on Human Pluripotential Stem Cell Research, in 2 NBAC, ETHICAL ISSUES IN HUMAN STEM CELL RESEARCH: COMMISSIONED PAPERS E-1, E-16 (2000) [hereinafter COMMISSIONED PAPERS] (alteration in original).
53) Some of these concerns are outlined in Deliberating Incrementally on Human Pluripotential Stem Cell Research and What Has the President Asked of NBAC?
Replenishment of leukocytes at early time periods following irradiation could result from proliferation and maturation of a pluripotential stem cell
subset that is protected from the damaging effect of radiation.
Pluripotential stem cells are present several days after fertilization and can also develop into any cell type but cannot develop into a fetus.
Multipotential stem cells are derived from pluripotential stem cells and can be found in adults.
Pluripotential stem cells
can also differentiate into various kinds of specialized cells when they are appropriately stimulated.