This proposal aims to develop and apply systematic approaches that can allow us to carry out the equivalent of genetic analysis of splicing regulation in cancer and pluripotent cells
Function and capability of these transcriptional genes and signaling pathways depend on the stage of development of the self-renewal and pluripotent cells
, indicating that these factors function in combination with other processes (Chickarmane et al.
Newcells' team can source tissues from patients, generate iPSC from these, and convert the pluripotent cells
into the particular cell types required to model the disease.
Prof Anand claims to have created the brain by converting adult skin cells into pluripotent cells
-- stem cells that can be programmed to become any tissue in the body.
The associated paper Metabolic rescue in pluripotent cells
from patients with mtDNA disease, authored by Hong Ma, et al.
The aim of carrying out these studies is to obtain pluripotent cells
from a cloned embryo.
Human pluripotent cells
resemble a cell type that appears slightly later in mammalian development, after the embryo has implanted in the uterus.
Researchers have been trying to grow "adult" red blood cells in the lab, using both embryonic stem cells and induced pluripotent cells
- adult cells that have been genetically "rewound" into an embryonic state.
That's a feat other pluripotent cells
generally can't accomplish, and it may indicate that STAP cells are totipotent, or capable of forming a complete organism.
Researchers at an Institute in Kobe City, located in western Japan, reports it has discovered a new method for creating pluripotent cells
in mice by simply exposing body cells to acidic liquids, and the cells can be reprogrammed to grow into any type of mature tissue, Xinhua news service reported.
The mice from which the cells were taken had been genetically engineered so their cells would glow green if Oct4, a gene associated with pluripotent cells
, was active.
represent a nice input population for the generation of many types of cells.