Its clinical programs are based on two platform technologies: pluripotent cells
and cell/drug delivery.
Immune-evasive pluripotent cells
would further extend the many possible applications of this technology.
Moreover, there is no standardized approach applicable to all cell types, and the development of personalized therapies based on patient-derived pluripotent cells
remains very expensive and time consuming.
Advances in cellular biology, exemplified by the discovery of induced pluripotent cells
, have reinforced the importance of cell observation during culturing in the fields of pharmaceuticals and regenerative medicine.
Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent cells
(iPSCs) are considered promising approaches to study diabetes.
The ensuing contributions discuss a number of specific cell types, including ocular surface cells, corneal stromal keratocytes, endothelial cells, crystalline lens cells, and limbal cells, as well as the dynamics and induction of pluripotent cells
, potential cell therapies, and gene therapy.
Human pluripotent cells
resemble a cell type that appears slightly later in mammalian development, after the embryo has implanted in the uterus.
Researchers have been trying to grow "adult" red blood cells in the lab, using both embryonic stem cells and induced pluripotent cells
- adult cells that have been genetically "rewound" into an embryonic state.
That's a feat other pluripotent cells
generally can't accomplish, and it may indicate that STAP cells are totipotent, or capable of forming a complete organism.
Researchers at an Institute in Kobe City, located in western Japan, reports it has discovered a new method for creating pluripotent cells
in mice by simply exposing body cells to acidic liquids, and the cells can be reprogrammed to grow into any type of mature tissue, Xinhua news service reported.
Specific topics include germ-cell differentiation from pluripotent cells
, adult stem-cell population in the human testis, embryonic stem cells from blastomeres maintaining embryo viability, in utero hematopoietic cell transplantation, and the metabolic framework of pluripotent stem cells and potential mechanisms of regulation.
The research, which provides proof-of-principle for the feasibility of combining induced pluripotent stem cell technology and genetic correction to treat muscular dystrophy, could present a major step forward in autologous cell-based therapies for DMD and similar conditions and should pave the way for testing the approach in reprogrammed human pluripotent cells
from muscular dystrophy patients.