plurihormonal

plurihormonal

/plu·ri·hor·mo·nal/ (-hor-mo´n'l) of or pertaining to several hormones.
References in periodicals archive ?
Mono- and plurihormonal thyrotropic pituitary adenomas: Pathological, hormonal and clinical studies in 12 patients.
Of note, we used the World Health Organization definition of plurihormone production, (1) which requires combinations of hormone or transcription factor immunoreactivity other than from those within a given family of adenoma; hence, plurihormonal adenomas do not include tumors with combinations of GH, PRL, and TSH, or of FSH and LH, for instance.
Apart from those exceptions, available clinical and serologic data were not discrepant with either the diagnosis obtained using the pituitary screen or the diagnosis obtained using all 7 stains, although significant diagnostic refinement was possible with the second immunohistochemical stage in the case of Pit-1 family members and possible plurihormonal tumors.
The adoption of this staged process for studying pituitary adenomas, with a screening step followed by additional IHC in the case of plurihormonal tumors or those with Pit-1 staining, would imply changes in our historical system, which entailed use of 6 IHC for anterior pituitary hormones supplemented by additional IHC as needed (CAM5.
We propose a clinical-serologic-immunohistochemical algorithm based on a screening step composed of IHC for Pit1, SF-1, and ACTH and an additional step for Pit-1 family members and plurihormonal tumors using IHC for PRL, GH, TSH, and CAM5.
Immunohistochemical test showed immunohistochemical test disclosed a plurihormonal adenoma, producing GH mainly.
True plurihormonal adenomas with unusual combinations of hormonal types are uncommon (see algorithm, Figure 2) and the pathologist should always reexamine the specimen in such cases to exclude the possibility of entrapped normal anterior pituicytes, some of which can occasionally be found at the edges of adenoma fragments, admixed with and surrounded by adenoma cells.
Invasion is characteristic of thyrotroph adenomas, silent corticotroph adenomas, and the unusual plurihormonal silent subtype 3 adenomas.
For some plurihormonal adenomas, electron microscopy continues to play an important role in determining cytodifferentiation and structure-function correlations.
32 Generally, aggressive behavior is a phenomenon of clinically silent hormone-containing adenomas and unusual plurihormonal adenomas as well as the rare lactotroph adenoma with GH immunoreactivity, known as the "acidophil stem cell adenoma.