(PL) Plumbago zeylanica In vitro:* Inhibited L.
The standard plumbagin
was used as positive control.
Ramakrishna, "Elicitor enhanced production of plumbagin
in suspension cultures of Plumbago rosea L.," Enzyme and Microbial Technology, vol.
Naidoo, "Conformational preferences of plumbagin
with phenyl-1-thioglucoside conjugates in solution and bound to MshB determined by aromatic association," Carbohydrate Research, vol.
(5-hydroxy-2-methyl-1,4-naphthoquinone), a quinonoid constituent isolated from the root of Plumbago zeylanica L., has been shown to exert anticarcinogenic, antiatherosclerotic, and antimicrobial effects [1-3].
Smith, "Effects of the chitin synthetase inhibitor plumbagin
and its 2-demethyl derivative juglone on insect ecdysone 20-monooxygenase activity," Experientia, vol.
(2-methoxy-5-hydroxy-1,4-naphthoquinone) is a natural naphthoquinone possessing various pharmacological activities such as antimalarial (16), antimicrobial (17), anticancer (18), cardiotonic (19) and antifertility action (20).
Antimicrobial activity of disiquinone and plumbagin
for the root of Diospyru mespiliformis.
Studies on the isolation of plumbagin
from in vitro and in vivo grown Drosera species.
, 5-hydroxy-2-methyl-1, 4-nepthoquinone isolated from Plumbago zeylanica cured R-plasmids in E.
The only active naphthoquinone, plumbagin
is an antiprotozoal compound with activity against Leishmania anzazorzensis and Leishmania doizovani in vitro and in vivo (Croft 1985; Fournet 1992) and antibacterial and antifungal activities (Gujar 1990).
The presence of some plant polyphenols such as piceatannol, taxifolin, coumestrol, plumbagin
, (-)-gallochatechin, (-)-rhein, (-)-epigallocatechin gallate, (-)-gallocatechin gallate, and (-)-epacatechin also decreased the number of revertants.