ploidy analysis

ploidy analysis

A flow cytometry technique which evaluates a cell’s chromosome content—a parameter of aggressiveness in cancer. In general, diploidy (i.e., the presence of 2 haploid sets of chromosomes) is a normal or near-normal state; in contrast, anaplastic and aggressive tumours are more often aneuploid or hyperdiploid. Ploidy analysis is used to prognosticate malignancies in bone (osteosarcoma), as well as in bladder, breast, colon, endometrial and ovarian carcinomas, and lymphoma.

ploidy analysis

Lab medicine A flow cytometry technique that evaluates a cell's chromosome content–a parameter of aggressiveness in CA; in general, diploidy–ie, the presence of 2 haploid sets of chromosomes, is a normal or near-normal state; in contrast, anaplastic and aggressive tumors are more often aneuploid or hyperdiploid; PA is used to prognosticate CA of bone–osteosarcoma, bladder, breast, colon, endometrium, lymphoma, ovary. See Flow cytometry, S-phase analysis.
References in periodicals archive ?
of the molecular genotyping assay (4 CHM, 4 PHM, 11 nonmolar) showed 100% concordance with p57 immunohistochemistry and DNA ploidy analysis by flow cytometry.
Nuclear DNA, chloroplast DNA and ploidy analysis clarified biological complexity of the Vandenboschia radicans Complex (Hymenophyllaceae) in Japan and adjacent areas.
Malignant granular cell tumor: Report of a case with DNA ploidy analysis.
Combining the results of ploidy analysis and insemination sperm concentration optimization, 75 sec UV irradiation of 1,075 [micro]W [cm.
Current instruments have been used to automate the microscopic urinalysis and histologic or cytologic slides for, as an example, DNA ploidy analysis.
Under the terms of the collaboration, researchers from KUMC and BioImagene will work together to develop new Companion Algorithms for DNA Ploidy analysis and other tumor markers, including breast, colon and gynecologic.
88,111-117) Ploidy analysis can be performed by flow cytometry or automated image cytometry and is applicable to urine cytology specimens as well as biopsy supernatant (112) and disaggregated TURB formalin-fixed, paraffin-embedded specimens.
Nuclear DNA, chloroplast DNA, and ploidy analysis clarified biological complexity of the Vandenboschia radicans complex (Hymenophyllaceae) in Japan and adjacent areas.
Category II factors are factors that have been studied extensively but await statistically robust trials and include parameters such as tumor volume, histologic type, and DNA ploidy analysis.
Herein we describe the cytogenetic and/or ploidy analysis of 5 patients with CCSK, and correlate this with clinicopathologic and p53 immunohistochemical findings.
The prognostic significance of ploidy analysis of PSCTs remains unclear because of the paucity of the cases.
DNA ploidy analysis was placed in category III (all other factors not sufficiently studied to demonstrate their prognostic value), indicating a lack of sufficient data to demonstrate prognostic value.