This study also confirmed that if the biopsy does not have nuclear pleomorphism
, loss of polarity, or cribriforming glands, it should not be diagnosed as HGD or carcinoma.
A central single assessment of less than 1/400 of the total number of endothelial cells in an eye with keratoconus may miss polymegathism, pleomorphism
, and endothelial cell damage in the region of eccentric cone since the sample observed might not be representative.
Histochemical studies showed a neoplasm made up of glial cells with nuclear pleomorphism
and eosinophilic cytoplasm arranged in sheets.
Fibrosarcoma shows a herring-bone-like growth pattern, denser cellularity, greater nuclear pleomorphism
, higher mitotic counts and lacks abundant collagen bands.
High power view of the tumor in the esophageal wall (b) showed the above- mentioned cells with bland looking nuclei without any atypia or pleomorphism
NUMEROUS KERATIN PEARLS AND FEW MITOTIC FIGURES WITH CELLULAR AND NUCLEAR PLEOMORPHISM
AND HYPERCHROMATISM WEREALSO SEEN, ADIAGNOSIS OF WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA WAS GIVE (H&E 20X).
Keywords: Glaucoma; Corneal endothelium; Corneal endothelial cell density; Pleomorphism
; Polymegathism; Selective laser trabeculoplasty; Confocal microscopy
was seen in 21 (58.3%) cases and was semiquantitatively assessed to be mild in 7 (19.4%), prominent in 11 (30.6%) and marked in 3 (8.3%) cases.
Microscopically, the tumor consisted of spindle cells arranged in bundles or incidentally, with elongated, oval, or thickened, hyperchromatic nuclei, with pleomorphism
. The mitotic activity was low, the cellularity was low to mild, and there were a lot of myxoid substances with aggregation of inflammatory cells around the spindle cells.
As with most histologic specimens, presence of the following increases likelihood of malignancy: necrosis, spindling, vesicular nuclei with large nucleoli, increased mitotic activity, high nuclear to cytoplasmic ratio, and pleomorphism
. (8) Wide local excision is the treatment of choice for benign GCT.
Necrosis, nuclear pleomorphism
, and mitotic activity were not detected.
STIC lesions exhibit histologic features of morphologic atypia (increased nuclear/cytoplasmic ratio, prominent nucleoli, increased proliferation with an intact basement membrane, variably stratified fallopian tube epithelium with nuclear pleomorphism
) and have evidence of TP53 mutations (J.